加味龟鹿二仙饮联合辅酶Q10对化疗源性卵巢储备功能减退的疗效

The Efficacy of Modified Guilu Erxian Decoction Combined with Coenzyme Q10 in the Treatment of Chemotherapy-induced Ovarian Reserve Dysfunction

目的:分析加味龟鹿二仙饮联合辅酶Q10在化疗源性卵巢储备功能减退患者中的临床疗效。方法:选择2021年11月至2023年5月在黔南布依族苗族自治州中医医院诊治的60例需进行化疗的女性肿瘤患者作为研究对象,按照随机数表法将其分为对照组和观察组,各30例。化疗期间,对照组患者使用辅酶Q10进行治疗,观察组患者使用加味龟鹿二仙饮联合辅酶Q10的治疗方法,比较两组患者的临床疗效。结果:化疗结束后1个月观察组患者的月经周期较对照短、月经量大于对照组;化疗结束后1个月观察组患者围绝经期症状发生率为23.33%,低于对照组的50.00%;化疗结束后1个月观察组患者的血清抗缪勒管激素(AMH)水平、窦卵泡数量(AFC)高于对照组,血清促卵泡生成激素(FSH)水平、FSH/促黄体生成素(LH)低于对照组;观察组患者的不良事件发生率低于对照组;观察组患者的治疗有效率为93.33%,高于对照组的70.00%,上述差异均具有统计学意义(P <0.05);化疗前及化疗结束后1个月两组患者血清谷丙转氨酶(ALT)、白蛋白(ALB)、总胆红素(TBIL)、血肌酐(Scr)比较,差异无统计学意义(P> 0.05)。结论:加味龟鹿二仙饮联合辅酶Q10对于化疗源性卵巢储备功能减退患者有较高应用价值,可改善患者月经周期、月经量、AMH、AFC、FSH、FSH/LH等指标,降低围绝经期的症状发生率、不良事件发生率。

Objective To analyze the clinical efficacy of Modified Guilu Erxian Decoction combined with coenzyme Q10 in patients with chemotherapy-induced ovarian reserve dysfunction.Methods A total of 60 female tumor patients requiring chemotherapy who were diagnosed and treated in Qiannan Buyei and Miao Autonomous Prefecture Traditional Chinese Medicine Hospital from November 2021 to May 2023 were selected as the research subjects.They were randomly divided into a control group and an observation group,with 30 cases in each group.During chemotherapy,patients in the control group were treated with coenzyme Q10,while patients in the observation group were treated with Modified Guilu Erxian Decoction combined with coenzyme Q10.The incidence of ovarian reserve dysfunction,primary efficacy indicators,safety indicators were compared between the two groups,and the efficacy was evaluated.Results One month after the end of chemotherapy,patients in the observation group had a shorter menstrual cycle and a greater menstrual volume compared to the control group.The incidence rate of perimenopausal symptoms in the observation group was 23.33%,lower than 50.00%in the control group.The serum anti-Müllerian hormone(AMH)level and antral follicle count(AFC)in the observation group were higher than those in the control group,while the serum follicle-stimulating hormone(FSH)level and FSH/luteinizing hormone(LH)ratio were lower than those in the control group.The incidence rate of adverse events in the observation group was lower than that in the control group.The effective rate of treatment in the observation group was 93.33%,higher than 70.00%in the control group,and these differences were statistically significant(P<0.05).There was no significant difference in serum alanine aminotransferase(ALT),albumin(ALB),total bilirubin(TBIL),and serum creatinine(Scr)between the two groups before and one month after chemotherapy(P>0.05).Conclusion Modified Guilu Erxian Decoction combined with coenzyme Q10 has high application value in the treatment of chemotherapy-induced ovarian reserve dysfunction,as it can improve menstrual cycle,menstrual volume,AMH,AFC,FSH,FSH/LH,etc,reduce the incidence of perimenopausal symptoms,and the incidence of adverse events.