IgG4相关性疾病肠道微生物组学的研究进展

Advances in gut microbiomes of IgG4-associated diseases

IgC4相关性疾病(IgG4-RD)是一种全身免疫介导的纤维炎症性疾病,可以累及几乎所有的器官和系统,临床主要表现为受累器官的肿大或肿块。其典型的病理学特征为病变组织中大量淋巴细胞浆细胞浸润、伴有席纹状纤维化和闭塞性静脉炎,大多数患者可有血清IgG4水平的升高。目前,该病的具体发病机制尚不清楚。近年来,肠道微生物组失调在自身免疫性疾病发生和发展中的作用机制逐渐被阐明。然而,对于肠道微生物组与IgC4-RD之间关联的了解仍然不足。因此,本文将对IgG4-RD的肠道微生物组学研究进展进行综述.

IgG4-associated disease(gG4-RD)is a systemic immune-mediated fibroinflammatory disease that can involve almost all organs and systems,and the main clinical manifestations are enlargement or mass of the affected organs.The typical pathological features of the disease are a large number of lymphocytoplasmic infiltration in the pathological tissue,accompanied by mat fibrosis and obliterated phlebitis,and most patients may have elevated serum IgG4 levels.At present,the specific pathogenesis of the disease is not clear.In recent years,the mechanism of intestinal microbiome dysregulation in the occurrence and development of autoimmune diseases has been gradually clarified.However,the association between the gut microbiome and IgG4-RD is still poorly understood.Therefore,this article will review the progress of intestinal microbiome research of IgG4-RD.