摘要
由结核分枝杆菌(Mycobacterium tuberculosis,MTB)引起的结核病是全球最主要的传染病之一,但目前对于MTB和宿主之间的相互作用机制知之甚少。动物模型和3D细胞模型为结核病的研究提供了更加全面和复杂的实验环境,有助于模拟疾病的多个方面。笔者对动物模型和3D细胞模型在结核病研究中的应用等方面进行综述,以期能为结核病的预防、诊断和治疗开辟新的途径。
Tuberculosis,caused by Mycobacterium tuberculosis(MTB),remains one of the world’s most significant infectious diseases,yet the mechanisms underlying MTB-host interactions are not fully understood.Animal models and 3D cell models offer a comprehensive and intricate experimental platform that facilitates the simulation of various aspects of tuberculosis pathophysiology.This review examines the application of these models in tuberculosis research,aiming to pave the way for advances in prevention,diagnosis,and treatment.
作者
黎超凡
陈志
Li Chaofan;Chen Zhi(Graduate School of Hebei North University,Zhangjiakou 075000,China;Department of Tuberculosis Medicine,Eighth Medical Center,PLA General Hospital,Beijing 100091,China)
出处
《中国防痨杂志》
CAS
CSCD
北大核心
2024年第12期1527-1534,共8页
Chinese Journal of Antituberculosis
基金
“十三五”艾滋病和病毒性肝炎等重大传染病防治国家科技重大专项(2018ZX10722-301-005)。
关键词
结核
疾病模型
动物
综述文献(主题)
Tuberculosis
Disease models,animal
Review literature as topic
