非结核分枝杆菌与其他呼吸道病原微生物合并感染的研究进展

Research progress on co-infection of non-tuberculous mycobacteria and other respiratory pathogens

随着人口老龄化程度逐年上升,结构性肺病患者不断增多,非结核分枝杆菌肺病(non-tuberculous mycobacteria pulmonary disease,NTM-PD)的发病率呈现增高趋势。大多数NTM-PD患者发病时已存在基础肺病,常同时合并感染多种病原微生物,进一步增加了NTM病诊治和疗效判定的难度,合并感染成为导致NTM-PD治疗成功率低和复发率高的重要原因之一。作者通过检索相关文献,对NTM合并感染的研究进展进行综述,以丰富临床工作者对NTM-PD患者肺部合并感染的认识,研究临床干预策略。

With the increasing aging of the population and the growing number of patients with structural lung diseases,the incidence of non-tuberculous mycobacteria pulmonary disease(NTM-PD)is on the rise.Most patients with NTM-PD have pre-existing underlying lung disease and are frequently co-infected with multiple pathogenic microorganisms,which further increases the difficulty of diagnosis and treatment of NTM disease as well as the evaluation of the efficacy of regimen.Co-infection is one of the major reasons for the low therapeutic success rate and high relapse rate.The authors reviewed the research progress of NTM co-infections by searching the relevant literature,in an attempt to enrich the understanding of pulmonary co-infections in patients with NTM-PD and to discuss their clinical intervention strategies.