经微创肺表面活性物质给药治疗早产儿呼吸窘迫综合征的效果及对动脉血气分析指标的影响

Effect of Minimally Invasive Pulmonary Surfactant Therapy on Respiratory Distress Syndrome in Premature Infants and Its Impact on Arterial Blood Gas Analysis

目的 分析经微创肺表面活性物质(LISA)给药治疗早产儿呼吸窘迫综合征(RDS)的效果及对动脉血气分析指标的影响。方法 选取2022年6月至2023年6月山西省儿童医院新生儿重症医学科收治的早产儿RDS148例,按随机数字表法分为常规给药组和微创给药组,各74例。微创给药组给予LISA治疗,常规给药组按照常规给药方法治疗。观察2组治疗情况、治疗前后动脉血气分析指标、住院期间并发症发生情况。结果 与常规给药组比较,微创给药组72 h内有创机械通气率、再次使用肺表面活性物质率更低(P <0.05),无创通气时间、住院时间更短(P <0.05)。与治疗前相比,治疗后2组动脉血氧分压(PaO2)、酸碱度(pH)升高(P <0.05),微创给药组高于常规给药组(P <0.05);2组动脉血二氧化碳分压(PaCO_(2))降低(P <0.05),微创给药组低于常规给药组(P <0.05)。与常规给药组比较,微创给药组支气管肺发育不良发生率更低(P <0.05)。结论 早产儿RDS经LISA治疗可改善治疗情况,改善动脉血气指标,控制并发症的发生风险。

Objective To analyze the effect of minimally invasive pulmonary surfactant therapy(LISA)on respiratory distress syndrome(RDS)in premature infants and its impact on arterial blood gas analysis indices.Methods 148 premature infants with RDS admitted to the Department of Neonatal Intensive Care Medicine of Shanxi Children's Hospital from June 2022 to June 2023 were randomly divided into the routine administration group and the minimally invasive administration group,with 74 cases in each group.The minimally invasive administration group received LISA treatment,while the conventional administration group was treated with the standard method.The treatment conditions,arterial blood gas analysis indices before and after treatment,and the occurrence of complications during hospitalization were observed.Results Compared with the routine administration group,the minimally invasive administration group showed a significantly lower rate of invasive mechanical ventilation and re-administration of pulmonary surfactant within 72 hours(P<0.05),as well as shorter duration of non-invasive ventilation and shorter hospitalization time(P<0.05).After treatment,both groups showed increased arterial partial pressure of oxygen(PaO2)and PH,with the minimally invasive group showing higher values than the conventional group(P<0.05).Both groups showed a decrease in arterial partial pressure of carbon dioxide(PaCO2),with the minimally invasive group having lower values than the conventional group(P<0.05).Additionally,the incidence of bronchopulmonary dysplasia in the minimally invasive group was lower than in the conventional group(P<0.05).Conclusion LISA treatment for premature infants with RDS can improve treatment outcomes,enhance arterial blood gas indices,and reduce the risk of complications.