放疗联合化疗治疗肝癌合并门静脉癌栓的临床研究

Clinical Observation of Radiotherapy Combined with Chemotherapy in Treatment of Liver Cancer Patients with Portal Vein Thrombosis

目的 探讨放疗联合化疗治疗肝癌合并门静脉癌栓患者的治疗效果。方法 选取2021年12月至2023年12月黑龙江省传染病防治院治疗的100例肝癌合并门静脉癌栓患者作为研究对象,采用随机数字表法将患者分为观察组和对照组,每组50例。对照组采用常规放疗治疗,观察组在对照组基础上采用放疗联合FOLFOX4(奥沙利铂+5-氟尿嘧啶或亚叶酸钙)方案进行治疗。观察联合治疗和单独放疗的疗效、患者身心状态以及治疗相关不良反应等。结果观察组有效率54%,显著高于对照组的32%(P <0.05)。治疗前2组患者生活质量评分差异无统计学意义(P> 0.05)。治疗后,2组患者生活质量评分显著高于本组治疗前(P <0.05),且观察组患者生活质量评分显著高于对照组,差异有统计学意义(P <0.05)。2组不良反应发生率差异无统计学意义(P> 0.05)。结论 肝癌合并门静脉癌栓放疗联合FOLFOX4方案化疗疗效好,不良反应小,患者身心状态好,值得临床参考。

Objective To explore the therapeutic effect of radiotherapy combined with chemotherapy on liver cancer patients with portal vein thrombosis.Methods 100 patients with liver cancer complicated with portal vein cancer thrombus who were treated at Heilongjiang Provincial Infectious Disease Prevention and Control Hospital from December 2021 to December 2023 were included in this study.The patients were randomly divided into the observation group and the control group,with 50 patients in each group.The control group received conventional radiation therapy,while the observation group received radiation therapy combined with the FOLFOX4 strategy on the basis of the control group.The efficacy of combination therapy and radiotherapy alone,as well as the patients'physical and mental state and treatment-related adverse reactions,were observed.Results The male to female ratio of enrolled patients was around 1∶1,and there was no statistically significant difference in general clinical information between the groups.The effective rate in the observation group was 54%,significantly higher than the 32%in the control group(P<0.05).Regarding quality of life,the scores of the two groups of patients before treatment were similar,with no statistical significance(P>0.05).After treatment,the quality of life of both groups was significantly improved compared to before treatment(P<0.05),and the quality of life in the observation group was significantly higher than in the control group,with statistical significance(P<0.05).The incidence of adverse reactions was similar between the two groups,with no significant difference(P>0.05).Conclusion Radiotherapy combined with FOLFOX4 chemotherapy for liver cancer complicated by portal vein thrombosis is effective,with minimal side effects,and improves the physical and mental state of patients.This approach is worth clinical consideration.