润燥止痒胶囊联合氯雷他定治疗尿毒症性皮肤瘙痒症的临床研究

Clinical Observation and Study on Combination of Runzao Zhiyang Capsules and Loratadine in the Treatment of Uremic Skin Itching

目的 探讨润燥止痒胶囊联合氯雷他定治疗尿毒症性皮肤瘙痒症的疗效。方法 选择2023年4月至2023年12月于河北省黄骅市人民医院内一科血液透析室治疗的尿毒症性皮肤瘙痒症患者100例,按病案号数字表随机分为观察组(n=50)和对照组(n=50)。对照组采用氯雷他定片单药治疗,观察组使用润燥止痒胶囊联合氯雷他定片治疗,2组患者均同时外涂保湿霜。比较2组治疗前后视觉模拟法(VAS)评分、改良Duo氏瘙痒评分、匹兹堡睡眠质量指数(PSQI)评分以及不良反应发生率。结果 观察组总有效率显著高于对照组(P <0.05)。2组患者治疗后VAS评分、改良Duo氏瘙痒评分及PSQI评分均低于本组治疗前(P <0.05),且观察组VAS评分、改良Duo氏瘙痒评分及PSQI评分均低于对照组(P <0.05)。结论 润燥止痒胶囊联合氯雷他定治疗尿毒症性皮肤瘙痒症效果优于单用氯雷他定,临床症状缓解效果更好,睡眠质量更高,具有一定的临床应用价值。

Objective To explore the therapeutic effect of Runzao Zhiyang Capsules combined with loratadine in the treatment of skin pruritus in patients with uremia.Methods 100 patients with skin pruritus who were treated in the hemodialysis room of the First Department of Huanghua People's Hospital in Hebei Province from April to December 2023 were randomly divided into an experimental group(n=50)and a control group(n=50)according to the number table of medical records.The control group was treated with a single dose of loratadine tablets,while the experimental group was treated with a combination of Runzao Zhiyang Capsules and loratadine tablets.Both groups of patients were also treated with topical moisturizing cream.The therapeutic effects of each group were observed and compared using the following indices:visual analogue scale(VAS)score,modified Duo's itching score,Pittsburgh sleep quality index(PSQI)score,and incidence of adverse reactions.Results The overall effective rate of the Runzao Zhiyang Capsule plus loratadine group was significantly higher than the loratadine-only group(P<0.05).After receiving treatment,the VAS score,improved Duo's score,and PSQI score were significantly lower than pre-treatment scores(P<0.05).The VAS score,improved Duo's score,and PSQI score of the Runzao Zhiyang Capsule plus loratadine group were significantly lower than the loratadine-only group(P<0.05).Conclusion The combination of Runzao Zhiyang Capsules and loratadine has a good therapeutic effect on uremic skin pruritus,can effectively alleviate itching symptoms,improve patient sleep quality,and has certain clinical application value.