摘要
目的分析血清胱抑素C(Cys-C)、白细胞介素-6(IL-6)联合尿微量白蛋白与尿肌酐(mALB/Cr)比值对糖尿病肾病(DN)的早期诊断价值。方法将2022年6月至2023年6月就诊于安徽医科大学第二附属医院的138例DN患者(DN组)、72例单纯糖尿病(DM组)为受试对象,另将同期于本院进行正常检查人群69名纳为对照组。测量比较3组血清Cys-C、IL-6水平及尿mALB/Cr比值;采用Logistic回归分析DN发生的影响因素;采用受试者工作特征(ROC)曲线分析血清Cys-C、IL-6水平联合尿mALB/Cr比值对DN的早期诊断价值。结果对照组、DM组与DN组性别、年龄、BMI比较,差异无统计学意义(P>0.05),3组糖尿病病程、血肌酐(Scr)、血尿氮素(BUN)、UAER、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)比较,差异有统计学意义(P<0.05)。血清Cys-C、IL-6及尿mALB/Cr比值:DN组>DM组>对照组,差异有统计学意义(P<0.05)。多因素logistic回归分析结果显示,糖尿病病程、Scr、BUN、UAER、Cys-C、IL-6及尿mALB/Cr比值均是DN发生的影响因素(P<0.05)。ROC曲线结果显示,血清Cys-C、IL-6及尿mALB/Cr比值联合检测对DN早期诊断的AUC为0.967,敏感度为0.806,特异度为0.864。结论DN患者血清Cys-C、IL-6水平及尿mALB/Cr比值均显著升高,且三者联合检测对DN早期具有较高诊断价值。
Objective To analyze the early diagnostic value of serum cystatin C(Cys-C),interleukin-6(IL-6),urinary microalbumin to creatinine(mALB/Cr)ratio in diabetes nephropathy(DN).Methods A total of 138 patients with DN(DN group)and 72 patients with simple diabetes(DM group)admitted to the Second Affiliated Hospital of Anhui Medical University from June 2022 to June 2023 were selected as subjects,another 69 people who had normal checkups in our hospital during the same period served as the control group.The levels of serum Cys-C,IL-6,and urine mALB/Cr ratio were measured and compared among the three groups;Logistic regression was used to investigate the factors influencing the development of DN;the value of serum Cys-C and IL-6 levels combined with urine mALB/Cr ratio for the early diagnosis of DN was analyzed using the receiver operating characteristic curve(ROC).Results There were no obvious differences in sex,age and BMI between the control group,the DM group and the DN group(P>0.05),but there were obvious differences in the course of diabetes,serum creatinine(Scr),blood urine nitrogen(BUN),UAER,low-density lipoprotein(LDL-C),and high-density lipoprotein(HDL-C)(P<0.05).There were significant differences in serum Cys-C,IL-6 and urinary mALB/Cr ratio among control group,DM group and DN group(P<0.05).Serum Cys-C,IL-6 and urinary mALB/Cr ratio were in DN group>DM group>control group,and the difference was statistically significant.ROC curve results showed that the combined detection of serum Cys-C,IL-6,and urine mALB/Cr ratio for early diagnosis of DN had an AUC of 0.967,a sensitivity of 0.806,and a specificity of 0.864.Conclusion The levels of serum Cys-C,IL-6,and urine mALB/Cr ratio in DN patients are obviously increased,and the combined detection of the three has high diagnostic value for early DN.
作者
许雯婷
包婷
聂广燕
王雪荣
XU Wenting;BAO Ting;NIE Guangyan;WANG Xuerong(Department of Nephrology,The Second Affiliated Hospital of Anhui Medical University,Hefei 230000,China)
出处
《转化医学杂志》
2024年第4期560-563,571,共5页
Translational Medicine Journal
基金
安徽省高校自然科学研究项目(KJ2021A0314)。