血府逐瘀汤联合穴位敷贴治疗冠心病稳定型心绞痛的临床研究

Clinical Study on the Combination of Xuefu Zhuyu Tang and Acupoint Application in the Treatment of Stable Angina Pectoris in Patients with Coronary Heart Disease

目的探究血府逐瘀汤联合穴位敷贴治疗冠心病稳定型心绞痛的应用价值。方法选取2022年1月至2024年1月北京中医药大学孙思邈医院冠心病稳定型心绞痛患者98例,按照随机数字表法分为观察组和对照组各49例。对照组予西药常规治疗,观察组在对照组治疗基础上予血府逐瘀汤联合穴位敷贴治疗。比较2组临床疗效、中医证候积分、炎症因子及治疗安全性。结果观察组总有效率(91.84%)高于对照组(73.47%)(P<0.05)。治疗后,观察组中医证候(胸胁胀闷、气短胸痛、面色晦黯、皮肤瘀斑、舌紫黯、脉沉细)评分、炎症因子C反应蛋白(CRP)、肿瘤坏死因子α(TNF-α)水平低于对照组(P<0.05)。2组不良反应发生率差异无统计学意义(P>0.05)。结论冠心病稳定型心绞痛给予血府逐瘀汤与穴位敷贴联合治疗疗效显著,可减轻患者主要中医证候,降低炎症因子水平,治疗安全性良好。

Objective To investigate the clinical efficacy of Xuefu Zhuyu Tang combined with acupoint application in the treatment of stable angina pectoris in patients with coronary heart disease.Method Ninety-eight stable angina pectoris patients with coronary heart disease were divided into two groups:control group(treated with conventional Western medicine)and observation group(treated with Xuefu Zhuyu Tang combined with acupoint application in addition to the control group),with 49 cases in each group.The clinical efficacy,TCM syndrome scores,levels of inflammatory factors(CRP,TNF-α),and treatment safety were compared.Result The total effective rate of the observation group(91.84%)was significantly higher than that of the control group(73.47%,P<0.05).The observation group’s main TCM syndrome scores(chest and rib distension,shortness of breath,chest pain,dull complexion,skin bruising,tongue purple and dark,pulse sinking)and inflammatory factor levels(CRP,TNF-α)were lower than those in the control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion The combination of Xuefu Zhuyu Tang and acupoint application demonstrated significant efficacy in the treatment of stable angina pectoris in patients with coronary heart disease.It can alleviate the main TCM symptoms,lower inflammatory cytokine levels,and ensure good treatment safety.