Metagenomic next-generation sequencing identified a brain abscess caused by mixed oral anaerobe infection:A case report

Fusobacterium vincentii brain abscesses are relatively rare.Here,we report our treatment of an anaerobic brain abscess caused by a mixed infection of Parvimonas micra,Streptococcus constellatus,Fusobacterium vincentii,and Bacteroides heparinolyticus diagnosed by metagenomic next-generation sequencing(mNGS).This is the first re-ported case of Fusobacterium vincentii in a brain abscess.This case highlights the possibility that oral anaerobic microbes can cause a brain abscess and demonstrates that mNGS has the potential to be deployed to provide rapid infection diagnosis and rationalize antimicrobial therapy for brain abscesses.