摘要
Cardiovascular disease is a significant cause of death in humans. Various models are necessary for the study ofcardiovascular diseases, but once cellular and animal models have some defects, such as insufficient fidelity. As anew technology, organoid has certain advantages and has been used in many applications in the study of cardiovasculardiseases. This article aims to summarize the application of organoid platforms in cardiovasculardiseases, including organoid construction schemes, modeling, and application of cardiovascular organoids. Advancesin cardiovascular organoid research have provided many models for different cardiovascular diseases in avariety of areas, including myocardium, blood vessels, and valves. Physiological and pathological models ofdifferent diseases, drug research models, and methods for evaluating and promoting the maturation of differentkinds of organ tissues are provided for various cardiovascular diseases, including cardiomyopathy, myocardialinfarction, and atherosclerosis. This article provides a comprehensive overview of the latest research progress incardiovascular organ tissues, including construction protocols for cardiovascular organoid tissues and theirevaluation system, different types of disease models, and applications of cardiovascular organoid models invarious studies. The problems and possible solutions in organoid development are summarized.
基金
supported by the National Science Fund for Distinguished Young Scholars(Grant No.82125004).
