内质网应激在非酒精性脂肪性肝病中的作用及相关靶向治疗

The role of endoplasmic reticulum stress in non-alcoholic fatty liver disease and related targeted therapies

非酒精性脂肪性肝病(NAFLD)是以肝脂肪变性为主要特征的一系列疾病谱的概括,是一种代谢相关性疾病,也是肝纤维化、肝硬化和肝癌的重要风险因子。内质网是调节脂代谢的核心场所,而非折叠蛋白反应是内质网应激(ERS)的重要过程。基于内质网在代谢相关疾病中的重要应激作用,本文将从ERS角度,探寻其与NAFLD之间的影响机制,对NAFLD病理发展过程中脂质代谢、炎症反应、细胞死亡、纤维化及ERS靶向治疗的相关研究进展进行综述。

Non-alcoholic fatty liver disease(NAFLD)is a series of diseases characterized by hepatic steatosis and is also a metabolism-associated disease and an important factor for liver fibrosis,liver cirrhosis,and hepatocellular carcinoma.Endoplasmic reticulum is a core organelle for the regulation of lipid metabolism,and unfolded protein response is an important process of endoplasmic reticulum stress(ERS).Based on the important stress role of endoplasmic reticulum in metabolism-associated diseases,this article explores the influencing mechanism between ERS and NAFLD and reviews the research advances in lipid metabolism,inflammatory response,hepatocyte death,fibrosis,and ERS-targeted therapies in the pathological development of NAFLD.