黄连素对肝脏疾病的防治作用及其机制

Preventive and therapeutic effects of berberine on liver diseases and its mechanism

黄连素是临床常用的清热解毒药,目前常规被用于治疗细菌性胃肠炎、腹泻等消化道疾病。但近期多项研究表明,黄连素可通过调控腺苷酸活化蛋白激酶、转化生长因子-β等蛋白通路及改变肠道菌群构成,对自身免疫性肝炎、病毒性肝炎、非酒精性脂肪性肝病及肝癌等疾病产生治疗作用,不仅为这些疾病的治疗提供新的药物选择,扩展了黄连素的潜在适应证范围,也为后续类似药物的研发提供了线索。本文旨在总结黄连素对各类肝脏疾病的治疗作用及其机制,为临床的有效应用提供参考。

Berberine is an antipyretic and detoxicating drug commonly used in clinical practice,and it is currently used for the routine treatment of gastrointestinal diseases such as bacterial gastroenteritis and diarrhea.However,several recent studies have shown that berberine can exert a therapeutic effect on the diseases such as autoimmune hepatitis,viral hepatitis,nonalcoholic fatty liver disease,and liver cancer by regulating the AMPK and TGF-βpathways and altering the composition of intestinal flora.This provides new drugs for the treatment of these diseases,expands the potential indications of berberine,and provides clues for the follow-up research and development of similar drugs.This article summarizes the therapeutic effect and mechanism of berberine on various liver diseases,in order to provide a reference for effective clinical application.