肺表面活性物质在新生儿呼吸窘迫综合征接受机械通气治疗中的应用效果及安全性

Application Effect and Safety of Pulmonary Surfactant in Mechanical Ventilation Treatment of Neonatal Respiratory Distress Syndrome

目的观察肺表面活性物质在新生儿呼吸窘迫综合征接受机械通气治疗中的应用效果及安全性。方法选取2022年1月-2023年9月在我院诊治的68例新生儿呼吸窘迫综合征患儿为研究对象,采用随机数字表法分为常规组和试验组,各组34例。常规组患儿接受机械通气治疗,试验组给予机械通气+肺表面活性物质治疗。比较两组治疗效果、血气指标、并发症发生率、机械通气时间及住院时间。结果试验组治疗总有效率(97.06%)高于常规组(85.29%)(P<0.05);两组治疗后PaO_(2)、pH、PaO_(2)/FiO_(2)均高于治疗前,PaCO_(2)均低于治疗前,且试验组PaO_(2)、pH、PaO_(2)/FiO_(2)均高于常规组,PaCO_(2)均低于常规组(P<0.05);试验组并发症发生率与常规组比较,差异无统计学意义(P>0.05);试验组机械通气时间、住院时间均短于常规组(P<0.05)。结论新生儿呼吸窘迫综合征采用肺表面活性物质与机械通气治疗可实现理想的治疗效果,提高总有效率,改善血气治疗,促进通气改善,缩短治疗进程,且无显著并发症,值得临床应用。

Objective To observe the application effect and safety of pulmonary surfactant in the treatment of neonatal respiratory distress syndrome with mechanical ventilation.Methods A total of 68 children with neonatal respiratory distress syndrome diagnosed and treated in our hospital from January 2022 to September 2023 were selected as the research objects.They were divided into routine group and experimental group(n=34)by random number table method.The routine group was treated with mechanical ventilation,and the experimental group was treated with pulmonary surfactant on the basis of the routine group.The therapeutic effect,blood gas indexes[arterial partial pressure of oxygen(PaO_(2)),arterial partial pressure of carbon dioxide(PaCO_(2)),pH,inhaled oxygen concentration(PaO_(2)/FiO_(2))],incidence of complications,mechanical ventilation time and hospitalization time were compared between the two groups.Results The total effective rate of treatment in the experimental group(97.06%)was higher than that in the routine group(85.29%)(P<0.05).After treatment,PaO_(2),pH and PaO_(2)/FiO_(2) in the two groups were higher than those before treatment,PaCO_(2) was lower than that before treatment,and PaO_(2),pH and PaO_(2)/FiO_(2) in the experimental group were higher than those in the routine group,PaCO_(2) was lower than that in the routine group(P<0.05).There was no significant difference in the incidence of complications between the experimental group and the routine group(P>0.05).The mechanical ventilation time and hospitalization time of the experimental group were shorter than those of the routine group(P<0.05).Conclusion Pulmonary surfactant and mechanical ventilation in the treatment of neonatal respiratory distress syndrome can achieve the ideal therapeutic effect,improve the total effective rate,improve blood gas treatment,promote ventilation improvement,shorten the treatment process,and have no significant complications,which is worthy of clinical application.