老年慢性萎缩性胃炎患者肠化特征与幽门螺杆菌感染及胃肠激素的 相关 性

Correlation between intestinal metaplasia characteristics and Helicobacter pylori infection and gastrointestinal hormones in the elderly with chronic atrophic gastritis

目的探讨老年慢性萎缩性胃炎(CAG)患者肠上皮化生(IM)特征与幽门螺杆菌(Hp)感染及胃肠激素的相关性。方法选择2019年1月至2023年6月安徽省当涂县人民医院收治的130例老年CAG伴IM患者作为IM组,同时期收治的130例老年CAG不伴IM患者纳入非IM组,分析IM特征与Hp感染及胃肠激素[胃蛋白酶原Ⅰ(PGⅠ)、胃蛋白酶原Ⅱ(PGⅡ)、胃泌素-17(G-17)]的相关性。采用SPSS 22.0统计软件进行数据分析。根据数据类型,分别采用t检验、方差分析或χ2检验进行组间比较。采用Pearson相关性分析评估患者IM特征与Hp感染及胃肠激素之间的相关性。结果IM组Hp感染比例及血清G-17水平高于非IM组;PGⅠ/PGⅡ低于非IM组,差异有统计学意义(P<0.05)。IM组Hp感染患者(Hp组)IM形态不完全型占比、重症炎症者占比及Sydney评分均高于非Hp感染者(非Hp组),差异有统计学意义(P<0.05)。IM组患者PGⅠ/PGⅡ比较,IM形态不完全型低于完全型,轻度炎症、中度炎症、重度炎症患者依次下降;G-17水平比较,IM形态不完全型高于完全型,轻度炎症、中度炎症、重度炎症患者依次升高,差异均有统计学意义(P<0.05)。Pearson相关性分析显示,IM患者Sydney评分与PGⅠ/PGⅡ呈负相关(r=-0.592;P<0.001);与G-17呈正相关(r=0.624;P<0.001)。结论Hp感染及PGⅠ/PGⅡ、G-17水平与IM的形态、炎症程度和Sydney评分有相关性。

Objective To investigate the correlation between intestinal metaplasia(IM)characteristics with Helicobacter pylori(Hp)infection and gastrointestinal hormones in the elderly with chronic atrophic gastritis(CAG).Methods From January 2019 to June 2023,130 elderly patients with CAG and IM in Dangtu People′s Hospital of Anhui Province were selected as the IM group,and 130 CAG elderly patients without IM as the non-IM group during the same period.The correlation between IM characteristics,Hp infection and gastrointestinal hormones[pepsinogenⅠ(PGⅠ),pepsinogenⅡ(PGⅡ),and gastrin-17(G-17)]was analyzed.SPSS 22.0 was used for data analysis.According to the data type,comparison between groups was performed using t test,analysis of variance or Chi-square test respectively.Pearson correlation analysis was used to evaluate the correlation between IM characteristics,Hp infection and gastrointestinal hormones.Results The proportions of Hp infection and serum G-17 level in the IM group were higher than those in the non-IM group(P<0.05),the PGⅠ/PGⅡwas lower than that in non-IM group,and the difference was statistically significant(P<0.05).The proportion of incomplete IM morphology,severe inflammation and Sydney score of the patients with Hp infection(Hp group)in the IM group were higher than those in the non-Hp infection group(non-Hp group),and the difference was statistically significant(P<0.05).PGⅠ/PGⅡin IM incomplete morphology in the IM group was lower than that of the complete morphology,and the PGⅠ/PGⅡin patients with mild,moderate and severe inflammation decreased in order.The G-17 level in IM incomplete morphology was higher than that of complete morphology,and the G-17 level increased in order in patients with mild,moderate and severe inflammation,with statistically significant differences(P<0.05).Pearson correlation analysis showed that the Sydney score of the IM patients was negatively correlated with PGⅠ/PGⅡ(r=-0.592;P<0.001)and was positively correlated with G-17(r=0.624;P<0.001).Conclusion Hp infection,PGⅠ/PGⅡand G-17 have correlation with IM morphology,inflammation degree and Sydney score.