氨基酸代谢异常在急性肾损伤向慢性肾脏病转变中的作用研究进展

Progress of research on the role of amino acid metabolism disturbance in the transition from AKI to CKD

急性肾损伤(AKI)的特点是肾功能迅速恶化,罹患后即使肾功能完全恢复,也可能会遗留肾脏损害进而导致慢性肾脏病(CKD)。目前,AKI转变为CKD的机制尚不完全清楚,AKI相关的氨基酸代谢异常可能在AKI向CKD转变过程中具有重要作用。本文综述了氨基酸代谢异常在AKI向CKD转变过程中的作用研究进展,旨在为防治AKI向CKD转变提供新思路。

Acute kidney injury(AKI)is characterized by rapid deterioration of kidney function,whose remnant renal injury may progressively lead to chronic kidney disease(CKD)even after the complete recovery of kidney function.At present,the mechanism of transition from AKI to CKD has not been fully understood,in which AKI-related abnormalities of amino acid metabolism may play an important role in the transition from AKI to CKD.This article reviewed the research progress on the role of abnormalities in amino acid metabolism in the transition from AKI to CKD,aiming to provide new ideas for preventing the transition from AKI to CKD.