基于CiteSpace对多囊卵巢综合征长链非编码RNA研究现状的可视化分析

Visualization Analysis of Polycystic Ovary Syndrome Long Noncoding RNA Research Based on CiteSpace

目的通过对多囊卵巢综合征(PCOS)长链非编码RNA(lncRNA)相关研究进行文献计量学统计及可视化分析以期探索该领域的研究现状、发展趋势与研究热点。方法以Web of Science核心数据库为文献数据来源,检索2015—2023年PCOS lncRNA相关文献,利用CiteSpace软件,对发文量、作者机构合作、基金、关键词等绘制相关知识图谱并分析。结果通过对108篇PCOS lncRNA相关文献可视化分析显示,中国是发文量居于首位的国家,位居第一的机构是山东大学,中国国家自然科学基金委员会给予最大力度的资助,关键词聚类分析表明PCOS lncRNA相关信号通路调控、相关受体激活剂、相关调控因子是该领域的研究热点。结论挖掘PCOS lncRNA相关调控因子、生物信息学分析、基因转录是PCOS治疗的新靶点,进行此类研究能够推动PCOS在临床治疗上的发展,并制定开发PCOS药物的新策略。

Objective This study aims to discuss the research hotspot and development trend in the field of polycystic ovary syndrome(PCOS)through bibliometric statistics and visual analysis of long noncoding RNA(lncRNA)related studies.Methods Utilizing the Web of Science core database as the literature data source,we searched for PCOS lncRNA-related literature from 2015 to 2023.CiteSpace software was used to conduct a visual analysis,including the annual distribution,citation trends,countries,institutions,funding sources and key words,as well as co-occurrence and cluster analysis of key words.Results The visual analysis of 108 PCOS lncRNA literature revealed that China was the country with the highest number of publications.The first contributing institution was the Shandong University.The national natural science fund of China gave the biggest funding.The keyword cluster analysis suggested that PCOS lncRNA signal pathway regulation,related receptor activators,and the expression of regulatory factors were the research hotspots in ovary syndrome lncRNA research.Conclusion LncRNA related regulatory factors,bioinformatics analysis,and gene transcription in PCOS are new targetsfor PCOS treatment,providing valuable insights for clinical therapy and new strategies for the development of PCOS-related pharmaceuticals.