放疗联合热疗治疗难治性复发性盆腔恶性肿瘤的疗效分析

Analysis of the Therapeutic Eff ect of Radiotherapy Combined with Hyperthermia on Refractory Recurrent Pelvic Malignant Tumors

探讨放疗联合热疗治疗难治性复发性盆腔恶性肿瘤的疗效。选取2021年1月—2022年12月在天津市肿瘤医院空港医院接受治疗的78例难治性复发性盆腔恶性肿瘤患者为研究对象,随机将其分为对照组和观察组两组,每组各39例。对照组仅采取放疗治疗,观察组采取放疗联合热疗治疗,对比两组患者的近期疗效、肿瘤标志物水平、生活质量、不良反应。结果显示,观察组治疗有效率为89.74%,明显高于对照组的69.23%(P<0.05);治疗后,观察组CEA、CA15-3、CA125、AFP水平均低于对照组(P<0.05);治疗后,观察组日常生活、精神状况、食欲、睡眠、疲乏状况等QOL评分均高于对照组(P<0.05);观察组骨髓抑制、放射性直肠炎、放射性膀胱炎、血栓性静脉炎、肝肾功能受损等不良反应发生率与对照组比较,无统计学差异(P>0.05)。研究发现,放疗联合热疗治疗难治性复发性盆腔恶性肿瘤的疗效显著,能有效抑制肿瘤增殖,降低肿瘤标志物水平,且患者耐受性较好,不良反应可控。

Exploring the efficacy of radiotherapy combined with hyperthermia in the treatment of refractory recurrent pelvic malignant tumors.78 patients with refractory recurrent pelvic malignant tumors who received treatment at Tianjin Cancer Hospital Airport Hospital from January 2021 to December 2022 were selected as the study subjects.They were randomly divided into a control group and an observation group,with 39 patients in each group.The control group received only radiotherapy treatment,while the observation group received radiotherapy combined with hyperthermia treatment.The short-term efficacy,tumor marker levels,quality of life,and adverse reactions of the two groups of patients were compared.The results showed that the effective rate of treatment in the observation group was 89.74%,significantly higher than the 69.23%in the control group(P<0.05);After treatment,the levels of CEA,CA15-3,CA125,and AFP in the observation group were lower than those in the control group(P<0.05);After treatment,the QOL scores of daily life,mental status,appetite,sleep,fatigue,etc.in the observation group were higher than those in the control group(P<0.05);There was no statistically significant difference(P>0.05)in the incidence of adverse reactions such as bone marrow suppression,radiation proctitis,radiation cystitis,thrombophlebitis,and liver and kidney dysfunction between the observation group and the control group.Research has found that the combination of radiotherapy and hyperthermia has significant therapeutic effects on refractory recurrent pelvic malignant tumors.It can effectively inhibit tumor proliferation,reduce tumor marker levels,and patients have good tolerance and controllable adverse reactions.