脑深部电刺激术对帕金森病患者眼球运动影响的研究进展

Research advances in the effect of deep brain stimulation on eye movement in patients with Parkinson disease

脑深部电刺激术(DBS)已经成为治疗帕金森病(PD)等神经系统变性疾病的一种成熟技术。该技术通过植入电极直接刺激特定的基底神经节核团,显著改善PD患者的临床症状,但其生理作用机制尚未完全阐明。眼球运动的控制机制涉及大脑皮质和基底神经节,与DBS的目标靶向网络存在广泛的重叠,但目前将DBS与眼球运动分析相结合的研究相对较少。本文旨在探讨DBS与眼球运动控制之间的相互作用机制,深入理解DBS对眼动功能的影响,这对于优化刺激参数、提高治疗效果具有重要意义。此外,该研究为揭示DBS的作用机制及PD的病理生理学提供了新的视角。

Deep brain stimulation(DBS)has become an established technique for the treatment of neurodegenerative diseases such as Parkinson disease(PD).This technique significantly improves the clinical symptoms of PD patients by directly stimulating specific basal ganglia nuclei with implanted electrodes,but its physiological mechanism of action remains unclear.The control mechanisms of eye movement involve the cerebral cortex and basal ganglia,which are extensively overlapped with the targeted network of DBS,but there are relatively few studies on the combined analysis of DBS and eye movement.This article explores the interaction mechanism between DBS and eye movement control to deeply understand the influence of DBS on eye movement function,which is of great significance for optimizing stimulation parameters and improving therapeutic effect.In addition,these studies provide new perspectives for revealing the mechanism of action of DBS and the pathophysiology of PD.