帕金森病的脑血流调节研究进展

Research advances in cerebral blood flow regulation in Parkinson disease

脑血流直接影响脑内物质代谢和神经活动,与神经系统变性疾病的发生和发展密切相关。脑血流调节能力直接影响脑组织血流灌注的稳定性,是评价脑功能的重要指标。目前已发现帕金森病(PD)患者皮质灌注减少与认知功能下降密切相关,疾病晚期容易出现直立性低血压,进一步增加低灌注的风险,更加体现出脑血流调节能力在PD中的重要性。本文通过回顾文献,重点总结PD患者的脑血流调节机制:脑血流自动调节、血管舒缩反应、神经血管耦合、内皮依赖性反应,为探讨脑血流对帕金森病的影响提供新思路和方向。

Cerebral blood flow directly affects substance metabolism and neural activity in the brain,and it is closely associated with the development and progression of neurodegenerative diseases.The ability for cerebral blood flow regulation directly affects the stability of cerebral blood perfusion,which is an important indicator for evaluating brain function.At present,studies have shown that the reduction in cortical perfusion is closely associated with cognitive decline in patients with Parkinson disease,and orthostatic hypotension often occurs in the late stage of the disease,thereby further increasing the risk of hypoperfusion,which reflects the importance of the ability for cerebral blood flow regulation in Parkinson disease.By reviewing related articles,this article summarizes the mechanism of cerebral blood flow regulation in patients with Parkinson disease,such as cerebral blood flow autoregulation,cerebral vasomotor reactivity,neurovascular coupling,and endothelium-dependent response,so as to provide new ideas and directions for exploring the effect of cerebral blood flow on Parkinson disease.