肠道菌群在脊髓损伤后认知功能障碍中的研究进展

Gut microbiota in cognitive dysfunction after spinal cord injury:a review

脊髓损伤作为一种破坏性的中枢神经系统疾病,除了会损害患者的运动、感觉能力外还会引起不同程度的认知功能障碍,对患者的生活质量造成重大影响。近年来的研究表明肠道菌群与中枢神经系统功能之间存在密切的联系,尤其是在脊髓损伤患者中引起认知功能异常的机制方面引起了广泛关注。因此本文将围绕脊髓损伤后肠道菌群发生改变进而影响认知功能,从下丘脑-垂体-肾上腺轴、神经递质及免疫系统3个途径,探讨肠道菌群在脊髓损伤后认知功能障碍中的研究进展。

Spinal cord injuries,as a destructive disorder of the central nervous system,not only impair the patients’motor and sensory abilities but also lead to varying degrees of cognitive dysfunction,affecting the quality of life of the patients.In recent years,studies have found a close association between gut microbiota and central nervous system function,especially concerning the mechanism of cognitive dysfunction in the individuals with spinal cord injuries.This paper reviews the progress in the role of gut microbiota in cognitive dysfunction after spinal cord injuries via three pathways:the hypothalamic-pituitary-adrenal axis,neurotransmitters,and the immune system.