椒蒿的抗炎作用及其分子机制研究进展

Research progress on anti-inflammatory effect and molecular mechanism of Artemisia dracunculus

炎症反应是许多疾病的病理基础,可局部侵染也可作用于全身,与多种疾病的发病机制密切相关.近年来,在越来越多传统抗炎药物呈现出不良反应的背景下,广大学者对中药相关用途探索的研究日渐增多.椒蒿作为菊科蒿属草本植物,具有毒性低、用途广泛的特点,可用于调节代谢、镇痛、抗抑郁、抗氧化、调节免疫、抑菌、抗炎、抗寄生虫等多种疾病的治疗,且椒蒿对多种疾病的治疗作用及潜能与其抗炎机制有密切联系.现总结近年来相关文献,从椒蒿对免疫细胞和炎症因子的调节机制以及对炎症相关信号通路的介导作用等方面进行综述,以期为椒蒿未来应用于临床试验及治疗提供理论参考.

Inflammation is the pathological basis of many diseases,which can infect locally or act on the whole body,and is closely related to the pathogenesis of many diseases.In recent years,in the background of more and more traditional anti-inflammatory drugs showing adverse reactions,scholars have been exploring the use of traditional Chinese medicine in the ascendant.As an herb in the Asteraceae(daisy)family,Artemisia dracunculus possesses low toxicity and a wide range of uses and can be applied to the regulation of metabolism,analgesia,antidepressant,antioxidant,immune regulation,antibacterial,anti-inflammatory,antiparasitic,and other treatment of a variety of diseases.In-depth studies have revealed that the therapeutic effects and potential of Artemisia dracunculus for a variety of diseases are closely related to its anti-inflammatory mechanism.This article will summarize the relevant literature in recent years and review the research progress of the mechanism of Artemisia dracunculus on the regulation of immune cells and inflammatory factors,as well as its mediation of inflammation-related signaling pathways,intending to provide theoretical references for future application of Artemisia dracunculus in clinical trials and treatments.