Recent developments in the physical structure of solid formulations:a comprehensive review

固体制剂物理结构的研究进展

Solid formulations represent the most widely used dosage forms,and their structural attributes significantly impact the efficacy of drugs.Consequently,delving into the study of solid formulation structures is of paramount importance.This paper employs bibliometrics to summarize references on solid formulations and physical structure over the past 5 years,providing a visual representation through CiteSpace.Additionally,we explore influential factors affecting the structure of solid formulations at three distinct levels:raw material,intermediate,and final product.It delves into the discussion of various characterization techniques employed to analyze the physical structure of solid formulations.The techniques include scanning electron microscopy,transmission electron microscopy,X-ray diffraction,nuclear magnetic resonance,LF-nuclear magnetic resonance,thermal analysis,and terahertz.Emphasis is placed on the significance of investigating formulation structures,serving as a found ational step for future research and development in this field.This comprehensive approach aims to contribute to the understanding and advancement of solid formulations for enhanced drug effectiveness.

固体制剂作为最广泛使用的剂型,其结构显著影响药物的有效性。因此,深入研究固体制剂结构是至关重要的。本文采用文献计量学的方法总结了近五年固体制剂和物理结构方面的文献,并利用CiteSpace软件提供了可视化分析。此外,在三个不同的水平上探讨了固体制剂结构的影响因素:原材料、中间体和最终产品。最后,深入讨论了固体制剂物理结构的各种表征技术,如扫描电子显微镜、透射电子显微镜、X射线衍射、核磁共振、低场核磁共振、热分析和太赫兹等。本综述强调了固体制剂结构研究的重要意义,为该领域的进一步研究和发展奠定了基础。这种全面的方法旨在促进固体制剂的理解和进步,以提高药物的有效性。