Forkhead box K1 deficiency alleviates ischemia-reperfusion-induced acute kidney injury

Objective To investigate the effect and mechanism of forkhead box K1 (FOXK1) in acute kidney injury(AKI),and to provide new ideas and targets for preventing and treating AKI.Methods Three models of AKI were established:30 male specific pathogen free wild type C57BL/6 mice aged 8-10 weeks and weighing 22-24 g were randomly divided into saline group(0.9%normal saline 0.1 ml/10 g,intraperitoneal injection),lipopolysaccharide(LPS) group(LPS solution 10 mg/kg,intraperitoneal injection),cisplatin group (cisplatin solution 20 mg/kg,intraperitoneal injection),ischemia-reperfusion (IR) group,and sham-operated group by the random number table,with 6 mice in each group.