Study of kynurenine pathway metabolites and their dynamic association with clinical symptoms in depressed patients with suicidal ideation

Objective To explore whether there are abnormalities in the kynurenine pathway in patients with depression and suicidal ideation,and their dynamic relationship with clinical symptoms.Methods According to the DSM-5 diagnostic criteria,a total of 68 patients with depression were prospectively enrolled,including 28 males and 40 females,aged(M(Q_(1),Q_(3)) 22.0 (17.3,47.8) years,who were the inpatients in the Division of Mood Disorders of Shanghai Mental Health Center from July 2019 to July 2022.