人群砷暴露与慢性肾脏病关系的Meta分析

Relationship between arsenic exposure in the population and chronic kidney disease:a meta-analysis

目的 系统评价人群砷暴露与慢性肾脏病风险的关系。方法 以砷和慢性肾脏病为关键词,在PubMed、Web of Science、The Cochrane Library、中国知网、万方、SinoMed和维普数据库进行检索,经提取资料与质量评价,使用Stata 14.0软件进行Meta分析、敏感性分析和发表偏倚评价。结果 共纳入15篇文献,包括17项研究结果,Meta分析结果表明,人群砷暴露与慢性肾脏病风险存在正相关关系(OR=1.35,95%CI:1.17~1.55);研究之间存在一定异质性(I2=80.9%,P<0.001);敏感性分析显示本次结果较稳定;本次纳入文献不存在明显发表偏倚。结论 人群砷暴露会增大慢性肾脏病发病风险。

Objective To systematically review the relationship between arsenic exposure in the population and chronic kidney disease(CKD).Methods PubMed,Web of Science,The Cochrane Library,CNKI,WanFang Data,SinoMed,and VIP databases were used for searching for keywords of arsenic and chronic kidney disease.After extracting data and assessing the quality of the stud-ies,Stata 14.0 software was used to conduct meta-analysis,sensitivity analysis,and publication bias assessment.Results A total of 15 articles were included in this meta-analysis,which included 17 studies.The results showed that there was a positive association be-tween arsenic exposure in the population and the risk of CKD(odds ratio=1.35,95%CI:1.17-1.55),with certain heterogeneity be-tween the studies(I2=80.9%,P<0.001).The stability of the results was confirmed by sensitivity analysis.No significant publication bias was observed in the articles included.Conclusion Arsenic exposure in the population increases the risk of CKD.