长周期光纤光栅生物检测技术研究进展

Research progress in biodetection technology based on long period fiber grating

长周期光纤光栅通过纤芯基模与包层模之间的耦合感应环境介质的变化,从而实现对外界环境的感知。其具有灵敏度高、体积小、背向反射低、抗电磁干扰等优点,已被应用于食品安全、环境检测、疾病诊断等各个领域。本文对近年来长周期光纤光栅在生物检测技术方面的应用进展做了总结,首先阐明了长周期光纤光栅生物检测的原理,其次,介绍了长周期光纤光栅表面生物功能膜的常用固定方法,然后对长周期光纤光栅在DNA、葡萄糖、细菌、癌症、病毒等生物物质检测方面的应用进行了总结。最后,分析了目前长周期光纤光栅在生物检测技术方面所面临的挑战,并对长周期光纤光栅生物检测技术的未来发展做了展望。

Long period fiber gratings(LPFGs)can sense changes in the environmental medium through the coupling between core fundamental modes and cladding modes,thereby achieving perception of the external environment.They have many advantages such as high sensitivity,small size,low back reflection,and resistance to electromagnetic interference,etc.,and have been applied in various fields such as food safety,environmental detection,disease diagnosis,and so on.In this paper,the progress of the application of LPFGs in biological detection technology in recent years is summarized.Firstly,the principle of LPFGs for biological detection is elucidated.Secondly,the common fixing methods of the biological functional films on the surface of LPFGs are introduced,and then the applications of LPFGs in the detection of biological substances such as DNA,glucose,bacteria,cancer,and viruses are summarized.Finally,the challenges faced by LPFGs in biological detection technology are analyzed,and the future development of LPFGs in biological detection technology is prospected.