非小细胞肺癌组织三结构域蛋白21和白细胞分化抗原147表达及意义

Expression and significance of TRIM21 and CD147 in NSCLC

目的:探究非小细胞肺癌(NSCLC)患者癌及癌旁组织标本中三结构域蛋白21(TRIM21)和白细胞分化抗原147(CD147)表达及意义。方法:选取接受手术治疗的NSCLC患者126例,采集癌及癌旁组织,分别定义为NSCLC组和癌旁组。分析TRIM21、CD147在癌和癌旁组织中的表达情况,探究两者与临床病理特征的关系。随访1年,分析存活组与病死组TRIM21、CD147的表达差异。结果:NSCLC组TRIM21阳性表达率低于癌旁组,CD147阳性表达率高于癌旁组(均P<0.05)。在组织分化、淋巴结转移及TNM分期等临床病理特征方面,TRIM21和CD147阳性率比较差异有统计学意义(均P<0.05)。在NSCLC患者中,TRIM21表达与CD147表达呈现负相关,且两者与淋巴结转移、TNM分期及组织分化具有相关性(均P<0.05)。随访结果显示,126例NSCLC患者中,有55例患者病死(病死组),71例患者存活(存活组)。存活组TRIM21阳性表达率高于病死组,CD147阳性表达率低于病死组(均P<0.05)。结论:NSCLC患者癌组织TRIM21表达降低而CD147表达升高,均与组织分化、淋巴结转移、TNM分期及预后相关。

Objective:To investigate the expression and significance of tripartite motif 21(TRIM21)and cluster of differentiation 147(CD147)in non-small cell lung cancer(NSCLC)tissues.Methods:A total of 126 patients with NSCLC who received surgical treatment were selected,and cancer and paracancer tissues were collected and defined as NSCLC group and paracancer group respectively.The expressions of TRIM21 and CD147 in cancer and paracancer tissues of NSCLC patients were analyzed.The relationship between TRIM21,CD147 expressions and clinicopathological features was explored.After 1 year of follow-up,the difference of TRIM21 and CD147 expression between survival group and death group was analyzed.Results:Compared with paracancer group,the positive expression rate of TRIM21 in NSCLC group was lower(all P<0.05).In tissue differentiation,lymph node metastasis and TNM stage,the differences in positive rates of TRIM21 and CD147 were significant(all P<0.05).In NSCLC patients,TRIM21 expression was negatively correlated with CD147 expression,and both were correlated with lymph node metastasis,TNM stage and tissue differentiation(all P<0.05).Follow-up data showed that of 126 NSCLC patients,55 died(death group)and 71 survived(survival group).Compared with death group,the positive expression rate of TRIM21 in survival group was higher,and CD147 was lower(all P<0.05).Conclusion:TRIM21 expression decreased and CD147 expression increased in cancer tissues of NSCLC patients,which were related to tissue differentiation,lymph node metastasis,TNM stage and prognosis.