2013~2023年神经重症患者镇痛镇静药物研究的文献可视化分析

Visualization analysis of research about analgesic and sedative drugs for neurocritical care patients from 2013 to 2023

目的分析神经重症患者镇痛镇静药物领域的研究现状和发展趋势。方法以PubMed数据库为文献数据来源,于2024年5月21日检索2013~2023年发表的神经重症患者镇痛镇静药物研究相关文献,应用CiteSpace 6.2 R6软件对纳入文献的国家(地区)、作者、关键词及术语等进行可视化分析。结果共纳入文献135篇,其中美国(38篇)、中国(15篇)、加拿大(15篇)发表的文献数量位居前3位。发文量最多的作者为Citerio Giuseppe(4篇)、Busl Katharina M(3篇)和Bellomo Rinaldo(3篇)。频次排在前5位的关键词分别为颅脑损伤(25次)、神经重症监护(20次)、颅内压(6次)、机械通气(6次)、谵妄(5次)。频次排在前5位的术语分别为神经重症监护(80次)、颅脑损伤(63次)、预后(22次)、颅内压(18次)、右美托咪定(18次)。术语聚类分析共形成10个有意义的聚类,可归纳为作用机制、药物类型、应用目的及药物不良反应4个方面。结合术语突现及术语时间线视图,目前研究热点主要聚焦于谵妄、机械通气、颅内压和神经功能等。结论神经重症患者镇痛镇静药物研究热度不减,该领域主要研究药物类型从苯二氮类药物和丙泊酚转向右美托咪定,研究重点仍是聚焦于镇痛镇静药物用于神经重症患者时对脑功能及预后的影响。

Objective To analyze the current research status and development trends in the field of analgesic and sedative drugs for neurocritical care patients.Methods Using PubMed database as the literature data source,relevant literatures on analgesic and sedative drugs for neurocritical care patients published from 2013 to 2023 were searched on May 21,2024.CiteSpace 6.2 R6 software was used to visualize the countries(regions),authors,keywords and terms included in the literatures.Results A total of 135 articles were included.The United States of America(38 articles),China(15 articles)and Canada(15 articles)ranked in the top three in terms of the number of publication.The authors with the highest number of publication were Citerio Giuseppe(4 articles),Busl Katharina M(3 articles)and Bellomo Rinaldo(3 articles).The top five keywords in terms of frequency were traumatic brain injury(25 times),neurocritical care(20 times),intracranial pressure(6 times),mechanical ventilation(6 times)and delirium(5 times).The top five terms in terms of frequency were neurocritical care(80 times),traumatic brain injury(63 times),prognosis(22 times),intracranial pressure(18 times)and dexmedetomidine(18 times).The term clustering analysis formed a total of 10 meaningful clusters,which can be summarized into four dimensions:the mechanism of action,drug type,application purpose and side effects of the drugs.Based on the terms bursting and timeline view,research hotspots mainly focused on delirium,mechanical ventilation,intracranial pressure and neurological function.Conclusions The research on analgesic and sedative drugs for neurocritical care continues to gain popularity.The main research drug types have shifted from benzodiazepines and propofol to dexmedetomidine.The research focus is still on the impact of analgesic and sedative drugs on neurological function and prognosis in neurocritical care patients.