缬沙坦联合氢氯噻嗪治疗肺源性心脏病合并高血压的临床效果

Clinical Effect of Valsartan Combined with Hydrochlorothiazide in Treatment of Pulmonary Heart Disease and Hypertension

目的:探讨缬沙坦联合氢氯噻嗪治疗肺源性心脏病(PHD)合并高血压的临床效果。方法:选取2023年8月—2024年8月南京医科大学附属泰州人民医院收治的86例PHD合并高血压患者作为研究对象,根据抽签法随机分为对照组和观察组,各43例。对照组给予常规治疗,观察组在对照组基础上联合缬沙坦和氢氯噻嗪治疗。比较两组治疗效果、心功能指标及不良反应发生率。结果:观察组治疗总有效率高于对照组(P=0.034)。治疗前,两组脑钠肽(BNP)、左心室质量指数(LVMI)、左心室质量(LVM)水平及6 min步行试验距离(6 MWD)比较,无统计学差异(P>0.05);治疗后,观察组BNP、LVMI、LVM水平低于治疗前,且观察组低于对照组(P<0.05);两组6 MWD长于治疗前,且观察组长于对照组(P<0.05)。两组不良反应总发生率比较,无统计学差异(P>0.05)。结论:缬沙坦联合氢氯噻嗪治疗PHD合并高血压的临床效果显著,能改善患者心功能,且安全性较高。

Objective:To investigate the clinical effect of valsartan combined with hydrochlorothiazide in treatment of pulmonary heart dis⁃ease(PHD)complicated with hypertension.Methods:A total of 86 patients with PHD and hypertension who were admitted to the Affiliated Taizhou People's Hospital of Nanjing Medical University from August 2023 to August 2024 were selected as the study subjects.They were randomly divided into control group and observation group by using lottery method,with 43 patients in each group.The control group received conventional treatment,while the observation group received a combination treatment of valsar⁃tan and hydrochlorothiazide on the basis of the control group.The treatment effects,cardiac function indexes and incidence of ad⁃verse reactions were compared between the two groups.Results:The total effective rate of treatment in the observation group was higher than that in the control group(P=0.034).Before treatment,there was no statistical difference in the levels of brain natriuretic peptide(BNP),left ventricular mass index(LVMI),left ventricular mass(LVM)and results of the 6-minute walk test distance(6 MWD)of the between the two groups(P>0.05).After treatment,the levels of BNP,LVMI and LVM in the observation group were lower than those before treatment,and the levels in the observation group were lower than those in the control group(P<0.05);the 6 MWD in the two groups was longer than that before treatment,and the 6 MWD in the observation group was longer than that in the control group(P<0.05).There was no significant difference in the total incidence of adverse reactions between the two group(P>0.05).Conclusion:Valsartan combined with hydrochlorothiazide has significant clinical effeets in the treatment of PHD complicat-ed with HTN,and can improve the cardiac function of patients,and reduce the incidence of adverse reactions.