氨溴特罗口服溶液联合阿奇霉素、孟鲁司特钠治疗支原体感染致咳嗽的临床效果分析

Analysis on Clinical Effect of Ambroxol Hydrochloride and Clenbuterol Hydrochloride Oral Solution Combined with Azithromycin and Montelukast Sodium in Treatment of Cough Caused by Mycoplasma Infection

目的:分析氨溴特罗口服溶液联合阿奇霉素、孟鲁司特钠治疗支原体感染致咳嗽的临床效果。方法:选取2023年5月—2024年7月惠州市第六人民医院收治的支原体感染致咳嗽患儿82例作为研究对象,随机分成对照组和观察组,每组41例。对照组给予阿奇霉素联合孟鲁司特钠治疗,观察组在对照组基础上联合氨溴特罗口服溶液治疗。对比两组治疗效果、症状消失时间、咳嗽程度及不良反应发生情况。结果:观察组总有效率高于对照组(P=0.043)。两组发热、肺部啰音消失时间比较,差异无统计学意义(P>0.05);观察组咳嗽、喘息消失时间短于对照组(P<0.05)。治疗前,两组日间咳嗽、夜间咳嗽评分比较,差异无统计学意义(P>0.05);治疗后,两组日间咳嗽、夜间咳嗽评分均低于治疗前,且观察组低于对照组(P<0.05)。两组不良反应总发生率比较,无统计学差异(P>0.05)。结论:氨溴特罗口服溶液联合阿奇霉素、孟鲁司特钠治疗支原体感染致咳嗽的临床效果显著,能够有效缓解患儿的咳嗽症状,促进其康复,且安全性较高。

Objective:To analyze the clinical effect of ambroxol hydrochloride and clenbuterol hydrochloride oral solution com-bined with azithromycin and montelukast sodium in treatment of cough caused by mycoplasma infection.Methods:A total of 82 children with cough caused by mycoplasma infection in Huizhou Sixth People's Hospital from May 2023 to July 2024 were se-lected as study subjects.They were randomly divided into control group and observation group,with 41 cases in each group.The control group was treated with azithromycin and montelukast sodium,while the observation group was treated with ambroxol hydro-chloride and clenbuterol hydrochloride oral solution on the basis of control group.The treatment effects,the time of symptom dis-appearance,the degree of cough and the occurrence of adverse reactions were compared between the two groups.Results:The total effective rate in observation group was higher than that in control group(P=0.043).There was no statistical difference in the disap-pearance time of fever and lung rales between the two groups(P>0.05).The disappearance time of cough and wheezing in observa-tion group was shorter than that in control group(P<0.05).Before treatment,there was no statistical difference in daytime and nighttime cough scores between the two groups(P>0.05).After treatment,the daytime and nighttime cough scores in two groups were lower than those before treatment,and the scores in observation group were lower than those in control group(P<0.05).There was no statistical difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion:Ambroxol hy-drochloride and clenbuterol hydrochloride oral solution combined with azithromycin and montelukast sodium has significant clini-cal effects in treatment of cough caused by mycoplasma infection,and can effectively relieve cough symptoms of children,promote their recovery,and have high safety.