摘要
Histone modifications are key factors in chromatin packaging,and are responsible for gene regulation during cell fate determination and development.Abnormal alterations in histone modifications potentially affect the stability of the genome and disrupt gene expression patterns,leading to many diseases,including cancer.In recent years,mounting evidence has shown that various histone modifications altered by aberrantly expressed modifier enzymes contribute to tumor development and metastasis through the induction of epigenetic,transcriptional,and phenotypic changes.In this review,we will discuss the existing histone modifications,both well-studied and rare ones,and their roles in solid tumors and hematopoietic cancers,to identify the molecular pathways involved and investigate targeted therapeutic drugs to reorganize the chromatin and enhance cancer treatment efficiency.Finally,clinical inhibitors of histone modifications are summarized to better understand the developmental stage of cancer therapy in using these drugs to inhibit the histone modification enzymes.
基金
supported by grants from National Natural Science Foundation of China(grant number:42125707,41931291)
Non-profit Central Research Institute Fund of Chinese Academy of Medical Sciences(grant number:2019PT310027)
Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences(grant number:2021-RC310-006,2021-I2M-1-018,2021-RC310-018,2020-RC310-008)
China Postdoc-toral Science Foundation(grant number:2022M710454).
