期刊文献+

Minimally invasive versus open esophagectomy for resectable thoracic esophageal cancer(NST 1502):a multicenter prospective cohort study 被引量:1

下载PDF
导出
摘要 Background:Whether minimally invasive esophagectomy(MIE)is superior to open esophagectomy(OE)in the treatment of esophageal squamous cell carcinoma(ESCC)is still uncertain.Therefore,this multicenter prospective study aimed to compare MIE with OE in postoperative parameters and long-term survival.Methods:All hospitalized patients with cT1b-3N0-1M0 thoracic ESCC treated by MIE or OE were enrolled from 19 selected centers from April 1,2015 to December 31,2018.The propensity score matching(PSM)was performed to minimize the selection bias.The basic clinicopathological characteristics and 3-year overall survival(OS)as well as disease-free survival(DFS)of two groups were compared by R version 3.6.2.Results:MIE were performed in 1,387 patients and OE in 335 patients.335 cases in each group were finally matched by PSM,and no significant differences in the essential demographic characteristics were observed be-tween the MIE and OE groups after PSM.Compared with OE,MIE had significantly less intraoperative bleeding,less total drainage volume,shorter postoperative hospital stay,and harvested significantly more lymph nodes(LNs)(all P<0.001).There were no significant differences in the major postoperative complications and death rates between MIE and OE.The 3-year OS and DFS were 77.0%and 68.1%in the MIE group versus 69.3%and 60.9%in the OE group(OS:P=0.03;DFS:P=0.09),and the rates were 75.1%and 66.5%in the MIE group versus 66.9%and 58.6%in the OE group for stage cII patients(OS:P=0.04,DFS:P=0.09),respectively.Conclusions:Compared with OE,MIE is a safe and effective treatment approach with similar mortality and morbidity.It has the advantages in harvesting more LNs,improving postoperative recovery and survival of stage cII ESCC patients.
出处 《Journal of the National Cancer Center》 2023年第2期106-114,共9页 癌症科学进展(英文)
基金 supported by the National Science and Technology Support Program(grant number:NKTRDP-2015BAI12B08-01).
  • 相关文献

参考文献2

二级参考文献14

  • 1胡海菁,黄飚,李春芳,李良,张应和.颈部淋巴结病变的MRI诊断分析[J].中国临床医学影像杂志,2006,17(1):9-11. 被引量:7
  • 2Ferlay J, Shin Hr, Bray F, et al. Estimates of worldwide bur- den of cancer in 2008: GLOBOCAN 2008[J]. Inter J Can- cer, 2010, 127(12): 2893-2917.
  • 3Sgourakis G. Detection of lymph node metastases in esoph- ageal cancer[J]. Expert Rev Anticancer Ther, 2011, 11(4): 601-612.
  • 4Alper F, Turkyilmaz A, Kurtean S, et al. Effectiveness of the STIR turbo spin-echo sequence MR imaging in evalua- tion of lymphadenopathy in esophageal cancer[J]. Eur J Ra- diol, 2011, 80(3): 625-628.
  • 5Kato H, Miyazaki T, Nakajima M. The incremental effect of positron emission tomography on diagnostic accuracy in the initial staging of esophageal carcinoma[J]. Cancer, 2005, 103(1): 148-156.
  • 6Lowe VJ, Booya F, Fletcher JG. Comparison of positron emission tomography, computed tomography, and endo- scopic ultrasound in the initial staging of patients with esophageal cancer[J]. Mol Imaging Biol, 2005, 7(6): 422-430.
  • 7Noji T, kondo S, Hirano S, et al. Computed tomography evaluation of regional lymph node metastases in patients with biliary cancer[J]. Br J Surg, 2008, 95(1): 92-96.
  • 8Edge SB, Compton CC. The American Joint Committee on Cancer: the 7th edition of the AJCC cancer staging manual and the future of TNM[J]. Ann Surg Oncol, 20L0, 17(6): 1471-1474.
  • 9Chan DS, Fielding P, Roberts SA, et al. Prognostic signifi cance of 18-FDG PET/CT and EUS-defined tumour charac- teristics in patients with oesophageal cancer[J]. Clin Radi- ol, 2013, 68(4): 352-357.
  • 10Greenstein AJ, Litle VR, Swanson S J, et al. Prognostic Sig- ni fi canee of the Number of Lymph Node Metastases in Esophageal Cancer[J]. J Am Coll Surg, 2008, 206(2): 239- 246.

共引文献23

同被引文献2

引证文献1

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部