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Resolving tumor evolution:a phylogenetic approach

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摘要 The evolutionary dynamics of cancer,characterized by its profound heterogeneity,demand sophisticated tools for a holistic understanding.This review delves into tumor phylogenetics,an essential approach bridging evolu-tionary biology with oncology,offering unparalleled insights into cancer’s evolutionary trajectory.We provide an overview of the workflow,encompassing study design,data acquisition,and phylogeny reconstruction.No-tably,the integration of diverse data sets emerges as a transformative step,enhancing the depth and breadth of evolutionary insights.With this integrated perspective,tumor phylogenetics stands poised to redefine our understanding of cancer evolution and influence therapeutic strategies.
出处 《Journal of the National Cancer Center》 2024年第2期97-106,共10页 癌症科学进展(英文)
基金 supported by the National Natural Science Founda-tion of China(approval number:32270677).
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