一氧化氮在哮喘中的双重角色:中西医结合治疗的视角与疗效评估

Dual Role of Nitric Oxide in Asthma:A Perspective and Efficacy Assessment of Integrated Traditional Chinese and Western Medicine Treatment

哮喘是一种慢性气道炎症性疾病,其特征为气道的过度反应性和可逆性气流受限。一氧化氮(nitric oxide,NO)作为一种关键的生物信号分子,在哮喘的病理生理机制中扮演了双重角色。NO不仅作为炎症的标志物反映气道炎症的程度,还通过影响平滑肌的收缩进而影响气流的通畅性。中医将哮喘归入“哮病”或“喘证”范畴,认为其与体内“气”的失调、风寒侵袭和痰湿阻滞有关。中医治疗哮喘的方法主要包括调节气血、舒解经络等手段。研究旨在综合中医和现代医学视角,探讨NO在哮喘机制中的角色及其综合疗效。研究目标包括评估NO在哮喘病理机制中的作用,探讨中医药对NO水平的调节作用,以及通过促进中西医结合治疗的临床应用,探索更有效的治疗策略,提升哮喘患者的生活质量。综合研究有望为哮喘的治疗提供新的视角和方法,推动科学研究进步,并为患者提供更全面和有效的治疗方案。

Asthma is a chronic airway inflammatory disease characterized by airway hyperresponsiveness and reversible airflow limitation.nitric oxide(NO),as a key biological signaling molecule,plays a dual role in the pathophysiological mechanism of asthma.NO not only serves as a biomarker of inflammation,reflecting the degree of airway inflammation,but also affects the patency of airflow by influencing the contraction of smooth muscle.In traditional Chinese medicine,asthma is classified under the categories of"Xiao disease"or"dyspnea syndrome",and it is believed to be related to the imbalance of"Qi"in the body,invasion of wind-cold,and obstruction of phlegm-dampness.The treatment methods of asthma in traditional Chinese medicine mainly include regulating Qi and blood,relaxing meridians,and other approaches.This study aims to explore the role of NO in the mechanism of asthma and its comprehensive therapeutic effect from the perspectives of both traditional Chinese medicine and modern medicine.The research goals include evaluating the role of NO in the pathological mechanism of asthma,exploring the regulatory effect of traditional Chinese medicine on NO levels,and exploring more effective treatment strategies through promoting the clinical application of integrated traditional Chinese and Western medicine,to improve the quality of life of asthma patients.This comprehensive study is expected to provide new perspectives and methods for the treatment of asthma,promote scientific research progress,and offer more comprehensive and effective treatment options for patients.