角膜屈光术后伤口愈合生物学标志物及影像学评估研究进展

Corneal wound healing after refractive surgery:progress in biomarker research and ancillary imaging examination

角膜屈光手术已成为矫正近视、远视和散光等视觉问题的常见治疗方式之一。然而,术后角膜伤口愈合过程复杂,涉及炎症反应、细胞迁移、基质重塑等多个环节,角膜具有独特的生物学性质,各种细胞因子和蛋白酶共同参与调控伤口愈合,促进角膜组织修复,保持角膜的光学透明性与稳定性。因此,更深入地了解角膜伤口愈合过程,识别相关生物标志物,并利用现代医学成像技术更准确、及时地监测角膜伤口恢复情况,有助于评估屈光术后患者的眼表免疫炎症状态,同时也有利于预防和治疗术后相关并发症。本文总结了各种细胞因子和蛋白酶在角膜伤口愈合中的作用,并探讨了现代影像学技术在角膜伤口愈合研究中的应用,以期为临床提供参考。

Corneal refractive surgery has become one of the common treatment methods for correcting vision problems such as myopia,hyperopia,and astigmatism.However,the postoperative corneal wound healing process is complex,involving multiple stages such as inflammatory responses,cell migration,and matrix remodeling.The cornea has unique biological properties,with various cytokines and proteases participating in the regulation of wound healing,promoting corneal tissue repair,and maintaining the optical transparency and stability of the cornea.Therefore,a deeper understanding of the corneal wound healing process,the identification of related biomarkers,and the use of modern medical imaging technology for more accurate and timely monitoring of corneal wound recovery can strengthen the assessment of the ocular surface immune-inflammatory status of patients after refractive surgery and facilitate the prevention and treatment of postoperative complications.This article summarizes the role of various cytokines and proteases in corneal wound healing and discusses the application of modern imaging technology in corneal wound healing research,aiming to provide a reference for clinical practice.