骨类器官的构建、评价与应用专家共识(2024版)

Expert consensus on the construction,evaluation and application of bone organoids(version 2024)

骨类器官能模仿骨组织复杂结构和功能,是类器官研究前沿技术,在骨疾病建模、骨损伤修复和药物筛选领域展现出巨大应用潜力。尽管当前骨类器官构建在矿化、骨髓、骨小梁、骨痂及编织骨等骨组织功能结构的研究中取得一定进展,但目前骨类器官研究存在诸多问题,如构建策略缺乏规范、评价缺少统一标准等,限制了其进一步推广应用。为规范骨类器官研究,由中国老年学和老年医学学会老年病学分会骨科专家委员会、中华医学会骨科学分会青年骨质疏松学组、中国医师协会骨科医师分会骨质疏松学组和上海中西医结合学会骨质疏松专业委员会组织有关专家,基于循证证据,制订《骨类器官的构建、评价与应用专家共识(2024版)》,共提出17条推荐意见,旨在规范骨类器官研究和临床应用,提升其在科研和临床应用中的价值。

Bone organoids can simulate the complex structure and function of the bone tissues,which makes them a frontier technology in organoid researches.Bone organoids show a tremendous potential of applications in bone disease modeling,bone injury repair,and medicine screening.Although advancements have been made so far in constructing bone organoids with functional structures like mineralization,bone marrow,trabecular bone,callus,woven bone,etc,the researches in this field are confronted with numerous challenges such as lack of standardized construction strategies and unified evaluation criteria,which limits their further promotion and application.To standardize researches in bone organoids,the Orthopedic Expert Committee of Geriatric Branch of Chinese Association of Gerontology and Geriatrics,the Youth Osteoporosis Group of Orthopedic Branch of Chinese Medical Association,the Osteoporosis Group of Orthopedic Surgeon Branch of Chinese Medical Doctor Association,and the Osteoporosis Committee of Shanghai Association of Integrated Traditional Chinese and Western Medicine organized related experts to formulate Expert consensus on the construction,evaluation,and application of bone organoids(version 2024)based on an evidence‑based approach.A total of 17 recommendations were put forth,aiming to standardize researches and clinical applications of bone organoids and enhance their value in scientific research and clinical practice.