含活性成分中药材对骨质疏松症的作用机制研究现状

Research status quo of function mechanism of Chinese herbal medicines containing active ingredients on osteoporosis

骨质疏松症(OP)是由于随着年龄的增长,骨量不断下降,骨的脆性增加,易于发生骨折的一种全身性的疾病。随着现代社会人口老龄化问题不断加剧,OP的患病率不断上升,这一问题逐渐成为关注热点。研究发现,淫羊藿、补骨脂、骨碎补、仙茅、女贞子、旱莲草、杜仲等中药材中含有的一些活性成分,通过滋补肝肾、填补肾精等作用可提高骨密度,减少骨吸收,进而降低骨质疏松性骨折的可能,对OP有一定的治疗作用。本文综述中药材中含有的生物活性成分在抗炎、抑制破骨细胞产生、促进成骨细胞发育和缓解OP等方面的作用,为中药在临床上治疗OP的合理应用提供一定参考。

Osteoporosis(OP)is a systemic disease,which is prone to fracture due to the continuous decline of bone mass and the increase of bone brittleness with age.With the aging of population in modern society,the prevalence of OP is rising,and this problem has gradually become a hot spot.It is found that some active ingredients contained in Chinese herbal medicines such as Epimedium brevicornu Maxim.,Psoralea corylifolia Linn.,Davallia trichomanoides Blume,Curculigo orchioides Gaertn.,Ligustrum lucidum Ait.,Eclipta prostrata(L.)L.and Eucommia ulmoides Oliv can improve bone mineral density,reduce bone resorption,and further reduce the possibility of osteoporotic fracture,which has a certain therapeutic efficacy on OP.In this paper,the bioactive components contained in Chinese crude drug are reviewed,which have the functions of anti-inflammation,inhibiting osteoclast production,promoting osteoblast development and relieving OP,so as to provide some reference for the rational application of Chinese materia medica in clinical treatment of OP.