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雌孕激素 P物质及5-羟色胺水平与产后抑郁的相关性分析

Correlations between the levels of estrogen,progesterone,substance P,5-hydroxytryptamine and postpartum depression
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摘要 目的 分析雌孕激素、P物质、5-羟色胺水平与产后抑郁的相关性。方法 选取2021年5月—2022年5月绍兴市第七人民医院确诊的产后抑郁患者61例为研究组,同期体检的健康产妇61例为对照组。采用全自动生化分析仪检测两组雌二醇、孕酮水平,采用酶联免疫吸附法(ELISA)检测两组血清P物质、5-羟色胺水平,并分析以上指标与产后抑郁的相关性。结果 相比对照组,研究组雌二醇[(176.49±17.68)pg/ml]、P物质[(6.58±0.79)μg/ml]、5-羟色胺[(429.17±42.94)pg/ml]水平较高,孕酮[(51.47±5.16)pg/ml]水平较低(t=53.200、21.020、41.290、60.320,均P<0.05)。雌二醇、P物质、5-羟色胺水平在轻度抑郁、中度抑郁、重度抑郁患者中依次升高,孕酮在轻度抑郁、中度抑郁、重度抑郁患者中依次降低(F=7.770、3.056、6.092、14.015,均P<0.05)。雌二醇、P物质之间呈正相关(r=0.528、P<0.05),雌二醇、5-羟色胺之间呈正相关(r=0.574、P<0.05),孕酮、P物质之间呈负相关(r=-0.542、P<0.05),孕酮、5-羟色胺之间呈负相关(r=-0.401、P<0.05)。雌二醇、孕酮、P物质、5-羟色胺为影响产后抑郁发生的危险因素(均P<0.05)。结论 雌二醇、P物质、5-羟色胺水平在产后抑郁患者血清中呈异常高表达,孕酮则呈异常低表达,且各指标之间呈线性相关,在产后抑郁早期诊断中具有重要价值。 Objective To analyze the correlations between the levels of estrogen,progesterone,substance P,5-hydroxytryptamine and postpartum depression.Methods A total of 61 patients diagnosed as postpartum depression in Shaoxing Seventh People's Hospital from May 2021 to May 2022 were selected as study group,and 61 healthy pregnant women after physical examination were selected as control group during the same time.The levels of estrogen and progesterone were detected by automatic biochemical analyzer,and the levels of substance P and 5-hydroxytryptamine in serum of the two groups were detected by enzyme-linked immunosorbent assay(ELISA),and the correlations between the above indicators and postpartum depression were analyzed.Results Compared with control group,estradiol[(176.49±17.68)pg/ml],substance P[(6.58±0.79)μg/ml],5-hydroxytryptamine[(429.17±42.94)pg/ml]levels in study group were high-er,and progesterone level[(51.47±5.16)pg/ml]in study group was lower(t=53.200,21.020,41.290,60.320,all P<0.05).The levels of estradiol,substance P,and 5-hydroxytryptamine increased successively in mild depression group,moderate depression group,and severe depression group,while progesterone level decreased successively in mild depression group,moderate depression group,and severe depression group(F=7.770,3.056,6.092,14.015,all P<0.05).There was a positive correlation between estradiol and substance P(r=0.528,P<0.05),there was a positive correlation between estradiol and 5-hydroxytryptamine(r=0.574,P<0.05),there was a nega-tive correlation between progesterone and substance P(r=-0.542,P<0.05),there was a negative correlation between progesterone and 5-hydroxytryptamine(r=-0.401,P<0.05).Estradiol,progesterone,substance P,and 5-hydroxytryptamine were risk factors for postpartum depression(P<0.05).Conclusion Estradiol,substance P,and 5-hydroxytryptamine levels are abnormally high expressed in serum of patients with postpartum depression,while progesterone is abnormally low expressed,and the above-mentioned indicators are linearly corre-lated,which have important value in early diagnosis of postpartum depression.
作者 赵云飞 郑春美 黄磊 ZHAO Yun-fei;ZHENG Chun-mei;HUANG Lei(Shaoxing Seventh People's Hospital,Shaoxing,Zhejiang 312000,China)
出处 《中国妇幼保健》 CAS 2024年第22期4368-4371,共4页 Maternal and Child Health Care of China
基金 浙江省医药卫生科技计划项目(2019KY231)。
关键词 雌孕激素 P物质 5-羟色胺 产后抑郁 Estrogen and progesterone Substance P 5-Hydroxytryptamine Postpartum depression
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