脓毒症发生发展机制与TIM基因家族的关联

Association between the pathogenesis and development of sepsis and TIM gene family

脓毒症是由机体对感染、创伤等的一系列失控反应引起的危及生命的器官功能障碍。近年来研究发现炎症反应、免疫功能紊乱、细胞凋亡、细胞自噬、凝血功能障碍等多种病理生理改变参与脓毒症的发生及发展,而人T细胞免疫球蛋白和黏蛋白结构域(T cell immunoglobulin mucin,TIM)蛋白及其单抗可能是脓毒症早期诊断、免疫治疗及预后评估的潜在靶点。本文对脓毒症的发病机制及其与黏蛋白基因家族之间的关联进行概述,以期为脓毒症诊断与治疗的研究提供新的思路。

Sepsis is a life-threatening organ dysfunction caused by a series of uncontrolled reactions of the host to infection,trauma,and other factors.In recent years,research has found that various pathological and physiological changes such as inflammation,immune dysfunction,cell apoptosis,autophagy,and coagulation dysfunction are involved in the occurrence and development of sepsis.The proteins encoded by T cell immunoglobulin mucin(TIM)may be potential targets for early diagnosis,immunotherapy,and prognostic evaluation of sepsis.This article provides an overview of the pathogenesis of sepsis and its association with the mucin gene family,in order to provide new ideas for the diagnosis and treatment of sepsis.