重组人干扰素α1b辅助治疗喘息性支气管炎患儿的临床效果

Clinical Effect of Recombinant Human Interferonα1b in the Adjuvant Treatment of Asthmatic Bronchitis In Children

目的探索重组人干扰素α1b辅助治疗喘息性支气管炎(AB)患儿的临床效果及对睡眠状态与runt相关转录因子3(RUNX3)、T淋巴细胞趋化因子受体3(CXCR3)表达的影响。方法选取郑州人民医院2020年2月至2023年7月收治的106例AB患儿为研究对象,按随机数字表法分为吸入剂组和干扰素组。吸入剂组接受常规雾化吸入剂治疗,干扰素组增加重组人干扰素α1b治疗,对比两组患儿症状消失时间、相关因子表达、睡眠状态。结果干扰素组咳嗽、喘息、哮鸣音及湿啰音消失时间短于吸入剂组(P<0.05)。两组治疗1周后RUNX3水平较治疗前升高,干扰素组高于吸入剂组;CXCR3水平较治疗前降低,干扰素组低于吸入剂组(P<0.05)。两组治疗1周后觉醒次数较治疗前减少,干扰素组少于吸入剂组;睡眠时间较治疗前增长,干扰素组长于吸入剂组(P<0.05)。结论重组人干扰素α1b辅助治疗可调节AB患儿相关因子表达,改善咳嗽、喘息等症状,调控睡眠状态。

Objective To explore the clinical effect of recombinant human interferonα1b in the adjuvant treatment of asthmatic bronchitis(AB)in children and its influence on sleep state,RUNt-related transcription factor 3(RUNX3)and T lymphocyte chemokine receptor 3(CXCR3)expression.Methods A total of 106 children with AB in Zhengzhou People’s Hospital from February 2020 to July 2023 were selected as the study objects,and were divided into inhalant group and interferon group by random number table method.The inhalant group was treated with conventional nebulized inhalant,and the interferon group was treated with recombinant human interferonα1b.Symptom resolution time,expression of related factors and sleep status were compared between the two groups.Results The disappearance time of cough,wheezing,wheezing and rales in interferon group was shorter than that in inhalant group(P<0.05).After 1 week of treatment,RUNX3 levels in two groups were higher than before treatment,and those in interferon group were higher than those in inhalant group.CXCR3 levels in interferon group were lower than those in inhalant group(P<0.05).After 1 week of treatment,the number of awakenings in two groups was less than before treatment,and interferon group was less than inhalant group.The sleep time level of interferon group was longer than that of inhalant group(P<0.05).Conclusion Recombinant human interferonα1b adjuvant therapy can regulate the expression of related factors in AB children,improve symptoms such as cough and wheezing,and regulate sleep state.