尼可地尔辅助治疗在冠心病不稳定型心绞痛患者中的应用价值

Application Value of Nicodil Injection in the Adjuvant Treatment of Patients with Unstable Angina Pectoris of Coronary Heart Disease

目的:探究尼可地尔辅助治疗在冠心病不稳定型心绞痛患者中的应用价值。方法:选取2021年2月—2023年10月宜春市人民医院收治的88例冠心病不稳定型心绞痛患者,按照随机数字法分为对照组和研究组,各44例。对照组行常规治疗,研究组在对照组基础上加用尼可地尔注射液辅助治疗。评估两组临床疗效、炎症因子水平、心功能指标及心绞痛发作情况。结果:研究组总有效率高于对照组(P<0.05)。治疗前,两组超敏C反应蛋白(hs-CRP)、肿瘤坏死因子-α(TNF-α)、心率、左心室射血分数(LVEF)、左心室舒张末期内径(LVEDD)比较,差异均无统计学意义(P>0.05)。治疗后,研究组hs-CRP、TNF-α、LVEDD均明显低于对照组,心率、LVEF均高于对照组,差异均有统计学意义(P<0.05)。治疗前,两组心绞痛发作频次、发作时间比较,差异均无统计学意义(P>0.05);治疗后,研究组心绞痛发作频次、发作时间均明显低于对照组,差异均有统计学意义(P<0.05)。结论:尼可地尔辅助治疗冠心病不稳定型心绞痛患者效果较好,可减少患者心绞痛的发作频次、时间,提高其心功能。

Objective:To explore the application value of Nicodil in the adjuvant treatment of patients with unstable angina pectoris of coronary heart disease.Method:A total of 88 patients with unstable angina pectoris from coronary heart disease treated in Yichun People's Hospital from February 2021 to October 2023 were selected and divided into control group and study group according to random number method,with 44 cases in each group.The control group received routine treatment,and the study group was supplemented with Nicodil on the basis of the control group.The clinical efficacy,inflammatory factor levels,heart function and angina pectoris were evaluated.Result:The total effective rate of the study group was higher than that of the control group(P<0.05).Before treatment,there were no significant differences in hypersensitive C reactive protein(hs-CRP),tumor necrosis faction-α(TNF-α),heart rate,left ventricular ejection fraction(LVEF)and left ventricular end-diastolic diameter(LVEDD)between two groups(P>0.05).After treatment,hs-CRP,TNF-αand LVEDD in the study group were significantly lower than those in the control group,and heart rate and LVEF were higher than those in the control group,the differences were statistically significant(P<0.05).Before treatment,there were no significant differences in frequency and duration of angina attacks between two groups(P>0.05).After treatment,the frequency and duration of angina pectoris attack in the study group were significantly lower than those in the control group,the differences were statistically significant(P<0.05).Conclusion:Nicodil is effective in the adjuvant treatment of patients with unstable angina pectoris of coronary heart disease.It can reduce the frequency and time of angina pectoris and improve their heart function.