以nCD64为指导的治疗方案在肺部感染患儿中的应用

Application of nCD64-guided Treatment Scheme in Children with Pulmonary Infection

目的:探究以nCD64为指导的治疗方案在肺部感染患儿中的效果。方法:将2022年12月—2023年12月宿迁市中医院收治的80例肺部感染患儿根据随机数字表法分为对照组和观察组,各40例。对照组进行常规肺部感染治疗,观察组以nCD64为指导进行治疗。比较两组治疗总有效率、住院时间、抗感染药物应用时间、用药不良反应发生率、症状积分、临床肺部感染评分(CPIS)及炎症反应指标[血清肿瘤坏死因子-α(TNF-α)、白介素-6(IL-6)及白介素-8(IL-8)]。结果:观察组治疗总有效率显著高于对照组,住院时间及抗感染药物应用时间均显著短于对照组,用药不良反应发生率显著低于对照组,差异均有统计学意义(P<0.05);治疗前两组症状积分、CPIS及炎症反应指标比较,差异均无统计学意义(P>0.05);治疗后观察组症状积分、CPIS及炎症反应指标均显著低于对照组,差异均有统计学意义(P<0.05)。结论:以nCD64为指导的治疗方案有助于提升肺部感染的临床效果,对炎症反应的控制效果更好,可促进患儿早期恢复,减少不良反应发生。

Objective:To investigate the effect of nCD64-guided treatment scheme in children with pulmonary infection.Method:A total of 80 children with pulmonary infection admitted to Suqian Traditional Chinese Medicine Hospital from December 2022 to December 2023 were divided into control group and observation group according to random number table method,with 40 cases in each group.The control group received routine treatment for pulmonary infection,and the observation group received treatment guided by nCD64.The total effective rate,hospital stay,antiinfective drugs application time,incidence of adverse drug reactions,symptom and sign scores,clinical pulmonary infection score(CPIS)and inflammatory response indexes[serum tumor necrosis factor-α(TNF-α),interleukin-6(IL-6)and interleukin-8(IL-8)]were compared between the two groups.Result:The total effective rate of the observation group was significantly higher than that of the control group,the hospital stay and antiinfective drugs application time were significantly shorter than those of the control group,and the incidence of adverse drug reactions was significantly lower than that of the control group,the differences were statistically significant(P<0.05).Before treatment,there were no significant differences in symptom scores,CPIS and inflammatory response indexes between the two groups(P>0.05).After treatment,the symptom scores,CPIS and inflammatory response indexes in the observation group were significantly lower than those in the control group,the differences were statistically significant(P<0.05).Conclusion:The nCD64-guided treatment scheme helps to improve the clinical effect of pulmonary infection,better control the inflammatory response,promote early recovery of children,and reduce the occurrence of adverse reactions.