不同剂量血必净注射液治疗重症肺炎患者的临床效果

Clinical Effect of Different Doses of Xuebijing Injection on Patients with Severe Pneumonia

目的:探究不同剂量血必净注射液治疗重症肺炎患者的临床效果。方法:选取2021年1月—2023年1月吉安市中心人民医院收治的90例重症肺炎患者,根据随机抽签法分三组,各30例。进行常规治疗基础上,常规组给予常规剂量血必净注射液(50 mL)治疗,低剂量组给予低剂量血必净注射液(30 mL)治疗,高剂量组给予高剂量血必净注射液(80 mL)治疗。比较三组的治疗效果、炎症因子[肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)、降钙素原(PCT)]、血气指标[动脉血二氧化碳分压(PaCO_(2))、动脉血氧分压(PaO_(2))、动脉血氧饱和度(SaO_(2))]。结果:三组治疗总有效率比较,差异有统计学意义(P<0.05)。治疗前,三组炎症因子、血气指标比较,差异均无统计学意义(P>0.05);治疗后,三组炎症因子、血气指标均得到改善,高剂量组TNF-α、IL-6、PCT、PaCO_(2)均低于常规组和低剂量组,PaO_(2)、SaO_(2)均高于常规组和低剂量组,且常规组TNF-α、IL-6、PCT、PaCO_(2)均低于低剂量组,PaO_(2)、SaO_(2)均高于低剂量组(P<0.05)。结论:血必净注射液治疗重症肺炎具有显著效果,能有效改善患者炎症因子与血气指标,且适当增加剂量可进一步提升疗效。

Objective:To explore the clinical effect of different doses of Xuebijing Injection on patients with severe pneumonia.Method:A total of 90 patients with severe pneumonia admitted to Ji’an Central People's Hospital from January 2021 to January 2023 were selected and divided into three groups according to random drawing method,with 30 cases in each group.On the basis of routine treatment,the conventional group was treated with conventional dose of Xuebijing Injection(50 mL),the low-dose group was treated with low dose of Xuebijing Injection(30 mL),and the high-dose group was treated with high dose of Xuebijing Injection(80 mL).The therapeutic effects,inflammatory factors[tumor necrosis factor-α(TNF-α),interleukin-6(IL-6),procalcitonin(PCT)],blood gas indexes[arterial partial pressure of carbon dioxide(PaCO_(2)),arterial partial pressure of oxygen(PaO_(2)),arterial oxygen saturation(SaO_(2))]of the three groups were compared.Result:The total effective rate of the three groups was compared,the difference was statistically significant(P<0.05).Before treatment,there were no significant differences in inflammatory factors and blood gas indexes among the three groups(P>0.05).After treatment,inflammatory factors and blood gas indexes in the three groups were improved,TNF-α,IL-6,PCT and PaCO_(2)in the high-dose group were lower than those in the conventional group and low-dose group,PaO_(2)and SaO_(2)were higher than those in the conventional group and low-dose group,and TNF-α,IL-6,PCT and PaCO_(2)in the conventional group were lower than those in the lowdose group,PaO_(2)and SaO_(2)were higher than those in low-dose group(P<0.05).Conclusion:Xuebijing Injection has a significant effect in the treatment of severe pneumonia,which can effectively improve the inflammatory factors and blood gas indexes of patients,and appropriate dosage can further improve the curative effect.