老年高血压病患者中医辨证分型与血清Hcy、IL-18及miR-124的相关性探究

Study on the correlation between TCM syndrome differentiation and serum Hcy,IL-18and miR-124in elderly patients with hypertension

目的:探讨老年高血压病患者中医辨证分型与血清同型半胱胺酸(Hcy)、白介素-18(IL-18)及微小核糖核酸(miR)-124的相关性。方法:纳入2021年1月~2023年12月我院收治的150例老年高血压病患者作为老年高血压组,另选取60例同期到我院行健康检查的老年志愿者作为对照组。对比两组血清Hcy、IL-18及miR-124相对表达水平。统计患者中医辨证分型情况,对比不同中医辨证分型患者一般资料、血清Hcy、IL-18及miR-124相对表达水平。结果:老年高血压组患者血清Hcy、IL-18水平高于对照组(P<0.05),miR-124相对表达水平低于对照组(P<0.05)。150例老年高血压病患者中,肝阳上亢证22例(14.66%)、痰饮内停证46例(30.67%)、肾阴亏虚证82例(54.67%)。肝阳上亢证组血清Hcy、IL-18水平低于痰饮内停证组、肾阴亏虚证组(P<0.05),miR-124相对表达水平高于其他两组(P<0.05)。结论:老年高血压病患者中医辨证分型与血清Hcy、IL-18及miR-124相对表达水平有一定关系,可作为老年高血压病患者中医辨证分型的客观指标。

Objective:To investigate the correlation between TCM syndrome differentiation and serum homocysteine(Hcy),interleukin-18(IL-18)and microrbonucleic acid(Mir-124)in elderly patients with hypertension.Methods:150elderly hypertension patients admitted to our hospital from January 2021to December 2023were included as the elderly hypertension group,and 60elderly volunteers who went to our hospital for health examination during the same period were selected as the control group.The relative expression levels of serum Hcy,IL-18and miR-124were compared between the two groups.The TCM syndrome differentiation and classification of patients were analyzed,and the general data,relative expression levels of serum Hcy,IL-18and miR-124of patients with different TCM syndrome differentiation and classification were compared.Results:The serum levels of Hcy and IL-18in the elderly hypertension group were higher than those in the control group(P<0.05),and the relative expression level of miR-124was lower than that in the control group(P<0.05).Among 150elderly hypertensive patients,there were 22cases(14.66%)of liver-yang hyperactivity,46cases(30.67%)of phlegm and fluid stagnation,and 82cases(54.67%)of kidney-yin deficiency.The serum levels of Hcy and IL-18in the liver-yang hyperactivity syndrome group were lower than those in the Tanyin inside-stopping syndrome group and the kidney-yin deficiency syndrome group(P<0.05),and the relative expression level of miR-124was higher than that in the other two groups(P<0.05).Conclusion:TCM syndrome differentiation and classification of elderly hypertension patients are related to the relative expression levels of serum Hcy,IL-18and miR-124,which can be used as an objective index for TCM syndrome differentiation and classification of elderly hypertension patients.