寻常型银屑病中医证型与血清miR-155、TGF-β1及PASI评分相关性研究

Study on correlation between TCM syndrome type of psoriasis vulgaris and serum miR-155, TGF-β1and PASI scores

目的:探讨寻常型银屑病中医证型与血清miR-155、转化生长因子β1(TGF-β1)、银屑病皮损面积及严重程度指数(PASI)评分相关性研究。方法:回顾性选取2021年9月~2023年9月北京中医药大学东直门医院收治120例的寻常型银屑病患者为研究对象。统计寻常型银屑病中医证型分布情况,比较不同中医证型患者血清miR-155、TGF-β1水平及PASI评分,分析寻常型银屑病中医证型与血清miR-155、TGF-β1水平与PASI评分的关系。结果:120例寻常型银屑病患者中血热证51例、血瘀证38例、血燥证31例;不同中医证型寻常型银屑病患者血清miR-155、TGF-β1水平及PASI评分为血热证>血瘀证>血燥证( P <0.05);寻常型银屑病患者血清miR-155、TGF-β1水平与PASI评分呈正相关(r=0.649、 P <0.05,r=0.676、 P <0.05)。结果:寻常型银屑病中医证型与血清miR-155、TGF-β1水平及PASI评分具有良好的相关性,可以为寻常型银屑病患者辨证施治提供指导。

Objective: To investigate the correlation between traditional Chinese medicine(TCM) syndrome of psoriasis vulgaris and serum miR-155, transforming growth factor β1(TGF-β1) and psoriasis lesion area and severity index(PASI) scores. Methods: A total of 120patients with psoriasis vulgaris admitted from September 2021to September 2023Dongzhimen Hospital of Beijing University of Chinese Medicine were retrospectively selected as the study objects. The distribution of TCM syndrome types of psoriasis vulgaris was analyzed, the serum levels of miR-155, TGF-β1and PASI score of patients with different TCM syndrome types were compared, and the relationship between TCM syndrome types of psoriasis vulgaris and serum levels of miR-155, TGF-β1and PASI score was analyzed. Results: In 120cases of psoriasis vulgaris, 51cases were blood-heat syndrome, 38cases were blood-stasis syndrome, 31cases were blood-dryness syndrome. The serum levels of miR-155and TGF-β1and PASI scores of psoriasis vulgaris patients with different TCM syndromes were blood-heat syndrome>blood-stasis syndrome>blood-dryness syndrome( P <0.05). Serum miR-155and TGF-β1levels were positively correlated with PASI scores in psoriasis vulgaris patients( P <0.05). Conclusions: There was a good correlation between TCM syndrome type of psoriasis vulgaris and serum miR-155, TGF-β1level and PASI score, which could provide guidance for the dialectical treatment of psoriasis vulgaris patients.