四君补肺汤治疗NSCLC根治术后咳嗽的疗效及对肺功能、炎性因子的影响

Effectof Sijun Bufei Decoction in the treatment of cough after radical operation for NSCLC and the impact on pulmonary function and inflammatory factors

目的:观察四君补肺汤治疗非小细胞肺癌(NSCLC)根治术后咳嗽的疗效及对肺功能、炎性因子的影响。方法:选取2021年1月~2023年1月我院收治的NSCLC根治术后咳嗽患者150例,以随机数表法分为研究组与对照组,各自75例,给予对照组患者术后常规治疗,研究组则在对照组基础上予以四君补肺汤治疗。比较两组临床疗效,治疗前后的莱斯特咳嗽量表(LCQ-MC)评分、肺功能[1秒用力呼气容积(FEV 1 )、用力肺活量(FVC)、呼气峰值流速(PEF)]、炎性因子[白介素-4(IL-4)、白介素-6(IL-6)、白介素-10(IL-10)、γ干扰素(IFN-γ)]水平,并统计治疗期间患者不良反应的发生情况。结果:治疗后研究组临床疗效的总有效率为90.67%,高于对照组的77.33%( P <0.05)。治疗后两组患者LCQ-MC各维度评分、FEV 1 、FVC、PEF、IFN-γ水平较治疗前增加,且研究组高于对照组( P <0.05);同时日间咳嗽与夜间咳嗽评分、IL-4、IL-6及IL-10水平较治疗前减少,且研究组低于对照组( P <0.05)。此外,两组患者不良反应发生率之间的差异不显著( P >0.05)。结论:四君补肺汤改善NSCLC患者根治术后咳嗽的临床疗效确切,能有效缓解患者咳嗽症状,同时能改善肺功能与机体炎性反应,值得推荐。

Objective: To observe the effect of Sijun Bufei Decoction in the treatment of cough after radical operation for non-small cell lung cancer(NSCLC) and the impact on pulmonary function and inflammatory factors. Methods: 150patients with NSCLC who had cough after radical operation and were admitted to the hospital from January 2021to January 2023were selected. They were divided into the study group and the control group by random number table method, with 75cases in each group. The control group was given conventional treatment after operation, while the study group was treated with Sijun Bufei Decoction on the basis of the treatment of control group. The two groups were compared in terms of clinical efficacy, the Mandarin Chinese version of the Leicester Cough Questionnaire(LCQ-MC) score, pulmonary function [forced expiratory volume in one second(FEV 1 ), forced vital capacity(FVC) and peak expiratory flow(PEF)], and the levels of inflammatory factors [interleukin-4(IL-4), interleukin-6(IL-6), interleukin-10(IL-10) and interferon γ(IFN-γ)]. The incidence rates of adverse reactions were calculated. Results: The total clinical response rate in the study group after treatment was 90.67%, higher than 77.33% in the control group( P <0.05). After treatment, the LCQ-MC scores, FEV 1 , FVC, PEF and IFN-γ levels in the two groups increased. These indicators in the study group were higher than those in the control group( P <0.05). The daytime and nighttime cough scores, and the levels of IL-4, IL-6and IL-10decreased. These indicators in the study group were lower than those in the control group( P <0.05). There was no significant difference in the incidence of adverse reactions between the two groups( P >0.05). Conclusion: Sijun Bufei Decoction is effective in alleviating cough in patients with NSCLC after radical operation. It can effectively alleviate cough symptoms, and improve pulmonary function and inflammatory reactions.