柴芍六君子汤联合酪酸梭菌肠球菌三联活菌片对功能性消化不良患者疗效及G-17、PGⅠ的影响

Effect of Chaishao Liujunzi Decoction combined with Clostridium butyricum enterococcus triple viable tablet on functional dyspepsia and influence of G-17and PG-Ⅰ

目的:探究柴芍六君子汤联合酪酸梭菌肠球菌三联活菌片对功能性消化不良(FD)患者临床疗效及胃泌素-17(G-17)、胃蛋白酶原Ⅰ(PGⅠ)的影响。方法:选取2020年11月~2023年11月期间广州中医药大学深圳医院收治的FD患者82例进行研究,根据治疗方案差异分为研究组( n =44)与对照组( n =38)。对照组予以酪酸梭菌三联活菌片治疗,研究组在此基础上联合柴芍六君子汤治疗,2组疗程均为4周。比较两组治疗方案的临床疗效以及不良反应情况;比较两组患者治疗前后的中医证候积分、内脏敏感性指数和健康调查简表(SF-36)评分以及G-17、PGⅠ水平。结果:临床疗效比较,研究组总有效率明显更高( P <0.05);两组治疗后的中医证候主次症积分、内脏敏感性指数以及SF-36量表评分较治疗前均改善,且研究组改善更优( P <0.05);两组治疗后的血清指标包括PGⅠ、G-17水平较治疗前均改善,且研究组改善更优( P <0.05);而不良反应情况的比较,两组无显著差异( P >0.05)。结论:柴芍六君子汤联合酪酸梭菌三联活菌片针对FD的疗效显著,可有效缓解患者症状,提升胃功能,其可能与调节机体内G-17、PG Ⅰ表达水平有关。

Objective: To explore the clinical efficacy of Chaishao Liujunzi Decoction combined with Clostridium butyricum enterococcus trifecta tablets in patients with functional dyspepsia(FD) and the effects of gastrin-17(G-17) and pepsinogen Ⅰ(PG Ⅰ). Methods: A total of 82FD patients admitted to Shenzhen Hospital of Guangzhou University of Chinese Medicine from November 2020to November 2023were selected for this study, and divided into study group( n =44) and control group( n =38) according to the differences in treatment plans. The control group was treated with Clostridium butyricum triple viable tablets, and the study group was treated with Chaishao Liujunzi Decoction on this basis. The course of treatment in both groups was 4weeks. The clinical efficacy and adverse reactions of the two groups were compared. TCM syndrome score, visceral sensitivity index, SF-36score and G-17and PG-I levels were compared before and after treatment between the two groups. Results: The total effective rate of the study group was significantly higher( P <0.05). After treatment, the scores of TCM syndrome major and secondary, visceral sensitivity index and SF-36scale were improved in both groups, and the improvement was better in the study group( P <0.05). After treatment, the serum indexes including PG-I and G-17levels in both groups were improved compared with those before treatment, and the improvement was better in the study group( P <0.05). There was no significant difference in adverse reactions between the two groups( P >0.05). Conclusion: Chaishao Liujunzi Decoction combined with Clostridium butyricum triple viable tablet has a significant effect on FD, which can effectively relieve symptoms of patients and improve stomach function, which may be related to regulating the expression levels of G-17and PG-I in the body.