戊酸雌二醇联合黄体酮治疗围绝经期功能性子宫出血临床疗效观察

Clinical Efficacy of Estradiol Valerate Combined with Progesterone in the Treatment of Functional Uterine Bleeding During Perimenopause

目的探讨戊酸雌二醇联合黄体酮治疗围绝经期功能性子宫出血的临床疗效。方法选取医院妇产科2022年1月至12月收治的围绝经期功能性子宫出血患者75例,其中1月至6月收治的患者纳入对照组(37例),7月至12月收治的患者纳入观察组38例。两组患者均予黄体酮治疗,观察组患者加用戊酸雌二醇片口服。结果观察组总有效率为97.37%,显著高于对照组的81.08%(P<0.05)。观察组治疗后雌二醇水平显著高于对照组,促黄体生成素、卵泡刺激素水平均显著低于对照组(P<0.05)。结论戊酸雌二醇联合黄体酮治疗围绝经期功能性子宫出血,能进一步提高疗效,改善患者的性激素水平。

Objective To investigate the clinical efficacy of estradiol valerate combined with progesterone in the treatment of functional uterine bleeding during perimenopause.Methods A total of 75 patients with functional uterine bleeding during perimenopause admitted to the obstetrics and gynecology department of the hospital from January to December 2022 were selected.Among them,37 patients admitted from January to June were included in the control group,and 38 patients admitted from July to December were included in the observation group.Both groups were treated with progesterone,while the observation group received an additional dose of estradiol valerate.Results The total effective rate in the observation group was 97.37%,which was significantly higher than 81.08%in the control group(P<0.05).After treatment,the level of estradiol in the observation group was significantly higher than that in the control group,while the levels of luteinizing hormone and follicle stimulating hormone in the observation group were significantly lower than those in the control group(P<0.05).Conclusion Estradiol valerate combined with progesterone in the treatment of functional uterine bleeding during perimenopause can further improve the therapeutic effect and improve the patient′s sex hormone levels.