硫酸镁联合硝苯地平治疗妊娠期高血压综合征临床研究

Clinical Study of Magnesium Sulfate Combined with Nifedipine in the Treatment of Gestational Hypertension Syndrome SHI Xiaxia,FU Wenjing,LIU

目的探讨硫酸镁联合硝苯地平治疗妊娠期高血压综合征(简称妊高征)的临床疗效。方法选取医院2022年1月至2023年12月收治的妊高征患者116例,按治疗方案的不同分为对照组与研究组,各58例。对照组患者采用硫酸镁联合拉贝洛尔治疗,研究组患者采用硫酸镁联合硝苯地平治疗。两组患者均治疗7 d。结果研究组患者的总有效率为96.55%,明显高于对照组的82.76%(P<0.05);治疗后,研究组患者肾功能指标、血压指标及血清指标的改善效果明显优于对照组(P<0.05)。研究组患者的不良妊娠结局发生率明显低于对照组(P<0.05)。结论硫酸镁联合硝苯地平治疗妊高征的临床疗效较好,可改善肾脏功能、血压、血清指标,且安全性良好。

Objective To investigate the clinical efficacy of magnesium sulfate combined with nifedipine in the treatment of pregnancy induced hypertension syndrome(PIH).Methods A total of 116 patients with preeclampsia admitted to the hospital from January 2022 to December 2023 were selected and divided into the control group and a study group according to different treatment plans,with 58 cases in each group.The control group patients were treated with magnesium sulfate combined with labetalol,while the study group patients were treated with magnesium sulfate combined with nifedipine.Both groups were treated for 7 d.Results The total effective rate in the study group was 96.55%,which was significantly higher than 82.76%in the control group(P<0.05).After treatment,the improvement effect of renal function indicators,blood pressure indicators,and serum indicators in the study group was significantly better than that in the control group(P<0.05).The incidence of adverse pregnancy outcomes in the study group was significantly lower than that in the control group(P<0.05).Conclusion Magnesium sulfate combined with nifedipine in the treatment of preeclampsia has good clinical efficacy,which can improve renal function,blood pressure,serum indicators,and has good safety.